A Brief Overview of History, Pathogenesis and Treatment of Perforated Peptic Ulcer Disease with Evaluation of Prognostic Scoring in Adults

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A Brief Overview of History, Pathogenesis and Treatment of Perforated Peptic Ulcer Disease with Evaluation of Prognostic Scoring in Adults

June 1, 2021 Medicine and Medical 0

Peptic ulcer disease, which encompasses both stomach and duodenal ulcers, accounts for a large percentage of people who seek surgical help around the world. After decades of preference for surgical therapies such as stomach resections, vagotomy, and other operations, the discovery of H2-receptor antagonists revolutionized the thought of acid in peptic ulcer disease, contributing to the theory of acid suppression therapy for duodenal ulcer. After the Helicobacter pylori bug was identified as the causal cause, a triple medication treatment regimen for peptic illness was described, which was later adjusted to concurrent therapy to prevent antibiotic resistance. As a result of this recognition, the chapter on peptic ulcers has not yet come to an end. The surgical management of ulcer disease and its consequences is still a problem. All of the materials for this review were found using various search engines on the internet. By omitting cross references, duplicated citations, pediatric studies, case reports, iatrogenic and malignant perforations, and incorporating microbiological, immunohistochemistry, and studies with more than a ten-person sample size, the number of references was reduced to 34. Cohort studies, case-control studies In that order, prospective/retrospective, metaanalytical investigations were preferred. This article aims to provide a comprehensive review of all elements of peptic ulcer treatment. Endoscopy-proven cases of gastroduodenal ulcers necessitate the use of triple medication therapy to eradicate H. pylori.

Author (s) Details

Dr. V. Prabhu
Department of Surgery, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Sangli, Maharashtra, India.

A. Shivani
Department of Surgery, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Sangli, Maharashtra, India.

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