Emphasizing the Chemical Profiling and Antibacterial Efficacy of Different Ginger Accessions from Uttarakhand

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Emphasizing the Chemical Profiling and Antibacterial Efficacy of Different Ginger Accessions from Uttarakhand

March 6, 2021 Chemical Science 0

Natural compounds play a critical role in the manufacture of pharmaceuticals. Plant extracts have been used for a variety of purposes for many years, and are now being used as alternative medicines and food preservatives. Natural compounds have received a lot of attention in recent years, compared to synthetic compounds, because they have less or no side effects in therapeutics. The current study looks at the chemical composition and in vitro antibacterial activity of five ginger accessions obtained from various locations in Uttarakhand. PDB ID: 1QFE and PDB ID: 2VF5 are used to perform molecular docking between phytocompounds detected via GC-MS analysis and bacterial proteins. We can infer antibacterial activity regarding selected phytocompounds by comparing the scoring results of compositions in extracts of ginger rhizome with bacterial protein. The methanolic extract of ginger accession from Dharchula had good antibacterial effects, according to molecular docking analysis and antimicrobial tests. Despite their promise, the use of natural antimicrobials in food systems is restricted, primarily due to undesirable taste or aroma side effects. As a result, further research is required to determine the optimum levels of antibacterials that can be used safely in food systems without affecting sensory properties.

Author (s) Details

Jyotsna Dhanik
Department of Chemistry, Govind Ballabh Pant University of Agriculture & Technology, Pantnagar, 263145, U.S. NAGAR, Uttarakhand, India.

Ankita Verma
Department of Chemistry, Govind Ballabh Pant University of Agriculture & Technology, Pantnagar, 263145, U.S. NAGAR, Uttarakhand, India.

Neelam Arya
Department of Chemistry, Govind Ballabh Pant University of Agriculture & Technology, Pantnagar, 263145, U.S. NAGAR, Uttarakhand, India.

Om Prakash
Department of Chemistry, Govind Ballabh Pant University of Agriculture & Technology, Pantnagar, 263145, U.S. NAGAR, Uttarakhand, India.

Viveka Nand
Department of Chemistry, Govind Ballabh Pant University of Agriculture & Technology, Pantnagar, 263145, U.S. NAGAR, Uttarakhand, India.

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