Formulation and Evaluation of Press Coated Tablets of Lansoprazole: A Recent Study

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Formulation and Evaluation of Press Coated Tablets of Lansoprazole: A Recent Study

June 2, 2021 Pharmaceutical 0

Lansoprazole, a proton pump inhibitor, dissolves in an acidic environment, so it’s coated with enteric coating polymers to keep it from degrading. Lansoprazole is an acid-sensitive medication that degrades in the stomach’s acidic pH. The purpose of this study was to use the press coating technique to make enteric coated delayed release lansoprazole tablets. Methods: Direct compression was used to make core tablets, which were then tested for physicochemical qualities. As a coating layer, several combinations of ethyl cellulose, HPMC E15, and HPMC K4M were used to create press coated tablets. Dissolution tests were used to optimise the core and coated tablets. To determine the drug’s compatibility with various excipients, researchers used Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Scanning electron microscopy was used to assess the coat’s surface morphology and homogeneity (SEM). The ICH guidelines were used to assess the stability of the improved formulation. F5 containing ethyl cellulose: HPMC E15 (10:90) and F9 containing ethyl cellulose: HPMC K4M (25:75) were optimised among the various formulations based on superior drug release within 8 hours. DSC and FTIR tests confirmed that the medication was compatible with the excipients. The surface of the core tablet is consistently coated with coat by press coating, according to SEM pictures of tablets obtained. The formulations were shown to be stable in stability tests. As a result, the delayed release press coated tablets produced in this study transported lansoprazole to the intestine while also protecting it from degradation. Results: Among the various formulations F5 containing ethyl cellulose: HPMC E15 (10:90) and F9 containing ethyl cellulose: HPMC K4M (25:75) were optimized based on the better drug release within 8 h. DSC studies and FTIR studies revealed compatibility of drug with excipients. Obtained SEM photographs of tablets showed that the surface of core tablet is uniformly coated with coat by press coating. Stability studies showed that the formulations were stable. Conclusion: As a result, delayed release press coated tablets developed in this study delivered lansoprazole in the intestine and protected the drug from degradation.

Author (s) Details

Dr . D. Prasanthi
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-28, Telangana, India.

S. Prashanti
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-28, Telangana, India.

G. Meghana
G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad-28, Telangana, India.

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