Investigating the Effect of Ethanolic Extract of Trigonella foenum-graecum L. Seeds on Reproductive System of Male Albino Rats

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Investigating the Effect of Ethanolic Extract of Trigonella foenum-graecum L. Seeds on Reproductive System of Male Albino Rats

May 22, 2021 Medicine and Medical 0

The purpose of this chapter is to evaluate the antispermatogenic and antifertility properties of an ethanolic extract of Trigonella foenum-greacum seeds. It is one of the most extensively utilised plants for the treatment of numerous diseases in various traditional medical systems.

Methodology: An aqueous extract solution (250 mg/kg b.wt/day) was given orally to adult male albino rats for 45 days (Duckray strain).

The seeds extract inhibited spermatogenesis and made it impossible for normal untreated female rats with confirmed fertility to mate. The absolute and relative weights of the testis and seminal vesicle decreased significantly, whereas the weights of the ventral prostate and coagulating gland remained unchanged. In the cauda epididymis, sperm concentration and motility were likewise reduced. In the epididymal smear, there was a higher incidence of spermatozoa head and tail parts being separated. The testis of experimental animals demonstrated a halt in spermatogenesis at the secondary spermatocyte stage, as well as cellular debris buildup in the semineferous tubular lumen. The spermatids were underdeveloped, and the interstitial cells were thin and deteriorated. The spermatogonia, on the other hand, showed no signs of injury. Animals’ body weight was not affected by extract administration. The levels of hallmark testicular enzymes, such as sorbitol dehydrogenase, were found to be much lower, whereas lactate dehydrogenase and gamma-glutamyl transpeptidase were significantly higher.

Conclusion: These findings imply that T. foenum-greacum can cause male infertility in rats and should therefore be investigated further as a possible male antifertility agent.

Author(s) Details

Madhulika Singh
Department of Zoology, School of Science, Maharishi University of Information Technology, Lucknow -226013, India.

G. N. Verma
Department of Zoology, University of Lucknow, Lucknow-226006, India.

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