Liver Enzymes and HIV-infected Adults on HARRT: Evidence from a Randomised Cross-sectional Study in UPTH
This research looked at the levels of liver enzymes in HIV-infected adults who had been on highly active antiretroviral therapy (HAART) for at least a year. The study was planned as a randomised cross-sectional study to compare the aspartate aminotransferase [AST], alanine transaminase [ALT], and alkaline phosphatase [ALP] levels of 129 HIV-infected adult patients (46 males and 83 females). The University of Port Harcourt Ethics Committee issued ethical clearance (Ref: UPH/CEREMAD/REC/19) prior to the report. Clinical Chemistry Analyser (VS10) manufactured by Vitro Scient was used to collect venous blood samples and analyse liver enzyme levels. The findings were then split into two categories: usual and abnormal. The data was analysed using SPSS version 21 (IBM® Armonk, USA) and Graph Pad Prism (Version 8.0.2). The sex differences in mean were compared using the T-test, while the sex differences in categorised data were tested using Chi-square analysis. Males’ mean AST (27.6517.93 IU/L) and ALP (135.1310.87 IU/L) values were higher than females’ AST (27.2518.93 IU/L) and ALP (132.659.96 IU/L) values, while females’ ALT (34.6622.29 IU/L) values were higher than males’ (33.7518.14 IU/L); however, the discrepancies were not important. In conclusion, cholestatic abnormalities were found in more than 80% of the patients, while hepatocellular abnormalities were found in less than 35% of the patients. When compared to males with isolated (ALT/AST) abnormalities, more females were found to have mixed abnormalities. As a result, this research proposes that a randomised case-control study be performed to assess the degree of deviation from standard values.
Author (s) Details
Dr. Chinwe F. Anyanwu
Department of Pharmacology, Faculty of Basic Clinical Sciences, University of Port Harcourt, Nigeria.
Dr. Eric O. Aigbogun Jr.
Department of Anatomy, Faculty of Medical Sciences, Kampala International University, Western Campus, Uganda.
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