Recent Study on Copper-Promoted One-Pot Approach: Synthesis of Benzimidazoles

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Recent Study on Copper-Promoted One-Pot Approach: Synthesis of Benzimidazoles

March 13, 2021 Chemistry and Biochemistry 0

For the production of various 2-arylaminobenzimidazoles, a simple, one-pot method was produced. For the first time, a copper catalyst promoted domino C–N cross-coupling reaction for the generation of 2-arylaminobenzimidazoles is used in this process. The synthetic pathway involves a copper-based desulphurization/ nucleophilic substitution followed by domino intra and intermolecular C–N cross-coupling reactions, according to mechanistic studies. This newly developed copper-catalyzed method tackled some of the issues commonly encountered during the synthesis of 2-arylaminobezimidazoles, such as the use of costly catalytic systems and the poor reactivity of bromo precursors. The reaction procedure is straightforward, with good substrate tolerance, and yields of the desired products range from good to excellent. Copper, on the other hand, is more practical due to its simplicity, environmental acceptability, and cost effectiveness.

Author(s) Details

Dr. S. N. Murthy Boddapati
Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhar Pradesh 522510, India and Department of Chemistry, Sir C. R. Reddy College, PG Courses, Eluru, Andhra Pradesh 534002, India.

Ramana Tamminana
Department of Chemistry, GITAM Deemed to be University, Bengaluru Campus, Karnataka 562163, India.

Ravi Kumar Gollapudi
Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhar Pradesh 522510, India.

Sharmila Nurbasha
Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhar Pradesh 522510, India.

Mohamed E. Assal
Department of Chemistry, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Kingdom of Saudi Arabia.

Osamah Alduhaish
Department of Chemistry, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Kingdom of Saudi Arabia.

Mohammed Rafiq H. Siddiqui
Department of Chemistry, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Kingdom of Saudi Arabia.

Dr. Hari Babu Bollikolla
Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhar Pradesh 522510, India.

Syed Farooq Adil
Department of Chemistry, College of Science, King Saud University, P.O. 2455, Riyadh 11451, Kingdom of Saudi Arabia.

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