Recent Study on Synthesis of Novel Pyrimido Oxazine and Their Derivatives

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Recent Study on Synthesis of Novel Pyrimido Oxazine and Their Derivatives

March 6, 2021 Chemical Science 0

The present study used chalcone and urea as starting materials to make novel oxazine (1). The resulting compound 6-(4-chlorophenyl)-4-phenyl-6H-1,3-Oxazin-2-amine(2) was further reacted with ethyl 2-cyano-3,3-bis (methylthio) acrylate in DMF under reflux conditions, yielding novel 2-(4-chlorophenyl)-8-(methylthio)-6-oxo-4-phenyl-4,6,9,9 a-tetrahydro (3). Spectral methods were used to classify the synthesised compounds. At position 8, the compound (3) has a replaceable methylthio (-SCH3) group. Various nucleophiles, such as substituted aromatic amines, aromatic phenols, hetryl amines, and active methylene compounds, react with compound (3) to give 2- (4- chlorophenyl) -7- (substituted) In decent yields, -6-oxo-4-phenyl-4,6,9,9a-tetrahydropyrimido[2,1-b][1,3] oxazine-7-carbonitrile Since the cyano and thiomethyl groups are in close proximity in compound (3), it also undergoes cyclization, resulting in a polycyclic heterocyclic compound.

Author (s) Details

B. Sirsat Shivraj
P.G. Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded, India.

G. Jadhav Anilkumar
P.G. Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded, India.

S. Kale Prashant
P.G. Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded, India.

S. Jadhav Madhav
P.G. Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded, India.

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