Relevance of Achromobacter xylosoxidans in Non-Respiratory Tract Clinical Samples over a Decade (2008-2017): Findings from a Clinical Center in Southern Hungary

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Relevance of Achromobacter xylosoxidans in Non-Respiratory Tract Clinical Samples over a Decade (2008-2017): Findings from a Clinical Center in Southern Hungary

March 4, 2021 Pharmaceutical 0

Aims: Lactose-non-fermenting Gram-negative bacteria that are aerobic, motile (with peritrichous flagella), oxidase and catalase-positive belong to the genus Achromobacter. To evaluate the prevalence of A. xylosoxidans isolated from non-respiratory tract samples from adult inpatients and outpatients, as well as antibiotic resistance levels, retrospectively over a 10-year study period at a tertiary-care teaching hospital in Szeged, Hungary. Retrospective microbiological analysis was used in this study. Studying at the University of Szeged, which is affiliated with the Albert Szent-Györgyi Clinical Center, a primary- and tertiary-care teaching hospital in Hungary’s Southern Great Plain, from January 1, 2008 to December 31, 2017. The data was obtained using an electronic device. Antimicrobial susceptibility testing (AST) was done using the disc diffusion method and E-tests on Mueller–Hinton agar plates when required. Results: A total of 68 individual A. xylosoxidans isolates were identified over the course of the 10-year study period (6.83.6/year, range: 0-11 isolates). Isolation occurred 22 times in the first half of the study period (2008-2017), but 46 times in the second half (2013-2017). Inpatient departments provided the majority of the isolates (51 out of 68). Females made up 32 of the 68 patients (female-to-male ratio: 0.89). The susceptibilities of the A. xylosoxidans isolates (n=68) were as follows: high levels of susceptibility for imipenem and meropenem (n=63; 92.6 percent ), and moxifloxacin (n=55; 80.9 percent ), although higher rates of resistance were observed for sulfamethoxazole/trimethoprim (susceptible: n=36; 52.9 percent ), ciprof Conclusion: Since the prevalence of these pathogens in clinically relevant syndromes is poor, there is no literature on Achromobacter infections in the context of non-respiratory human infections. It should be noted that the difficulty in obtaining accurate identification (especially in low-resource settings) may be partly to blame for the bacteria’s infrequent classification as significant pathogens. In the future, advancements in diagnostic technology in routine clinical microbiology would almost certainly result in a change in the frequency of these bacteria being isolated.

Author (s) Details

Márió Gajdács
Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Eötvös utca 6., Hungary.

Marianna Ábrók
Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, 6725 Szeged, Semmewleis 6., Hungary.

Andrea Lázár
Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, 6725 Szeged, Semmewleis 6., Hungary.

Katalin Burián
Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, 6725 Szeged, Semmewleis 6., Hungary and Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, 6720 Szeged, Dóm tér 10., Hungary.

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