A Brief Review on Chronobiology and Chronotherapy of Hypertension

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A Brief Review on Chronobiology and Chronotherapy of Hypertension

June 7, 2021 Disease and Health 0

Hypertension affects more than 90% of all patients with cardiovascular disease (CVD) in the United States, and it is a major risk factor for end-organ injury, CVD, and mortality. Chronobiology, chronopharmacology, and chronotherapy in the management of hypertension have only been studied for a few decades. According to research conducted in the previous decade, our behaviour, such as what we eat, and the time of day, have an impact on blood pressure (BP) and cardiovascular disease (CVD). Furthermore, the potential of the night: day ratio of systolic BP to predict the risk of cardiovascular events is more accurate than office BP calculated only once. The evidence clearly reveals that nocturnal blood pressure is the type of blood pressure that is most consistently connected with cardiovascular risk prediction and allows for more frequent safety monitoring. The circadian rhythm is crucial for blood pressure regulation. As a result, the use of chronopharmacotherapy is required for a circadian condition like hypertension. Different drugs, on the other hand, have been investigated for their chronopharmacology and possible chronotherapy. This page discusses the chronobiology of hypertension, as well as the chronopharmacology and chronotherapy of the many medicines used to treat it. Researchers are likely to produce more creative chronopharmaceutical formulations for the control or treatment of hypertension now that they are aware of the risk factors connected with this illness problem.

Author (s) Details

K. Latha
G.Pulla Reddy College of Pharmacy, Mehidipatnam, Hyderabad 500 028, India.

M. U. Uhumwangho
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria.

S. A. Sunil
University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India.

M. V. Srikanth
University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India.

K. V. Ramana Murthy
University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India.

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