A Comprehensive Study on Anticancer Activity of Tridax procumbens Leaf Extracts on A549 and Hep G2 Cell Lines
Cancer is a ailment that is harshly accomplishing the worldwide human people. There is forever a determined demand for new cures to treat and hamper this mortal ailment. Scientific and research interest is illustration allure consideration towards uniformly derivative compounds, as they are deliberate to have less poisonous aftereffects distinguished to current situations to a degree a destructive agent, dissemination etc. Medicinal plant Tridax procumbens produces normally happening subordinate metabolites that is being examined for the anticancer exercises against A549 (human bronchi malignancy container line), Hep G2 (human liver abnormal growth in animate being container line) superior to the incident of new dispassionate drug.MTT and trypan sad dye forbiddance assays were used to determine the anticancer project of T.procumbens intoxicating, acetone, and liquid leaf extracts on picked human malignant container lines. The MTT assay depends the strength of practicable containers’ mitochondrial enzymes to convert the yellow dissolved seasoning MTT to the mauve sad mysterious formazan hurry, that is before restricted spectrophotometrically at 570 nm. The Trypan vulgar assay depends container staining. Cells are before added under a microscope utilizing a hemocytometer, and non-reasonable containers are tainted sky while practicable containers wait innocent.The liquid leaf extract of T. procumbens has not proved some anticancer exercise. However, acetone and intoxicating leaf extracts of T. procumbens has proved effective anticancer venture on A549 (human pleura tumor container line), Hep G2 (human liver abnormal growth in animate being container line).T. procumbens examined for anticancer potential by MTT assay and trypan sad expulsion assay. The acetone and intoxicating leaf extracts of T. procumbens have proved forceful anticancer project on picked human container lines.
Pittu Vishnu Priya,
Department of Pharmaceutical Biotechnology, Joginpally B.R Pharmacy College, Yenkapally (V), Moinabad (M), Telangana, Hyderabad-500 076, India.
A. V. S. S. S. Gupta,
Department of Pharmacology, Joginpally B.R Pharmacy College, Yenkapally (V), Moinabad (M), Telangana, Hyderabad-500 076, India.
A. Srinivasa Rao,
Department of Pharmacology, Bhaskar Pharmacy College, Yenkapally (V), Moinabad (M), Telangana, Hyderabad-500 076, India.
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Keywords: Anticancer activity, Tridax procumbens, 3-(4, 5-dimethyl-thiazole-2-yl)-2,5-diphenyl tetrazolium bromide assay, trypan blue exclusion assay, A549, Hep G2