A Critical Study of Hepatitis B Virus Genotypes and Mutation in 1762 & 1764 Nucleotides of X Gene in Chronic HBV Patients from Golestan Province—Iran

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A Critical Study of Hepatitis B Virus Genotypes and Mutation in 1762 & 1764 Nucleotides of X Gene in Chronic HBV Patients from Golestan Province—Iran

October 9, 2020 Biotechnology and Microbiology 0

Around 378 million individuals are estimated by the WHO to be chronic carriers of HBV and many of them develop progressive diseases, including cirrhosis and hepatocellular carcinoma. Genetic variants have been suggested to be associated with an increased risk of hepatocellular carcinoma caused by fulminant hepatitis B. The purpose of this research was to examine mutations in the x gene region of patients infected with HBV in the province of Golestan, Iran. In this study, 100 patients were reported. The viral DNA of Hepatitis B was extracted from plasma and precise primers were used to conduct PCR. 51 percent of the chronic HBV patients were male. The findings showed that A1762 T, G1764A double mutations modifying AGG to avoid codon TGA were present in 49 percent of patients. 27% and 24% of cases displayed mutation only at positions A1762 T and G1764A, respectively. This research revealed the existence of X gene mutations in patients infected with chronic HBV in the province of Golestan, Iran. The frequency of HBV X gene mutations in nucleotides of 1762 and 1764 was greater than that of nucleotides of 1762 and 1764. The overall prevalence in the world (34 percent).

Author (s) Details

Sareh Zhand
Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

Ghassem Rostamian
Department of Medicine, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Alijan Tabarraei
Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

Abdolvahab Moradi
Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

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