A New Convenient Synthesis of Tetra Substituted Pyrimidines and Their Antimicrobial Screening Report
An efficient and novel strategy has been developed using potassium carbonate as catalyst for
synthesis of 4-amino-2-methyl-6-(methylthio)pyrimidine-5-carbonitrile (3) by condensing acetamidine
hydrochloride (1) with bis(methylthio)methylene malononitrile (2) in DMF. Compound (3) is susceptible
to nucleophilic substitution reaction due to presence of methylthio group at sixth position, which is
replaced by different nucleophiles such as substituted anilines, phenols, hetryl amines and
compounds containing active methylene group to afford 6-substituted derivatives of 4-amino-2-methyl- 6-(methylthio)pyrimidine-5-carbonitriles (4a-7d). All newly prepared compounds were characterized by IR, 1H-NMR, Mass spectral analysis. Furthermore, these synthesized compounds were tested for antimicrobial activity. This procedure offers the advantages of mild reaction condition, easy work up, short reaction time and high yield.
Dr. S. P. Vartale
Department of Chemistry, PG Research Center, Yeshwant Mahavidyalaya Nanded-431602 (MS), India .
Dr. B. D. Kalyankar
Department of Chemistry, PG Research Center, Yeshwant Mahavidyalaya Nanded-431602 (MS), India.
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