A Smart Approach for Delivering of Risperidone using Euryale ferox Biopolymer Rate Controlling Flexi Films for Transvermillion Delivery

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A Smart Approach for Delivering of Risperidone using Euryale ferox Biopolymer Rate Controlling Flexi Films for Transvermillion Delivery

September 6, 2021 Pharmaceutical 0

The goal of this study was to develop and test risperidone-loaded bioflexi films for the treatment of autism. Biopolymer was extracted from Euryale ferox seeds (family Nymphaeaceae) for the production of bioflexi films using a cost-effective approach. Infrared spectroscopy (IR), differential scanning colorimetry (DSC), scanning electron microscopy (SEM), nuclear magnetic resonance (NMR), and cell line toxicity studies were used to evaluate the biopolymer recovered from the concentrate.

Methods: In a methanol and water solvent solution, bioflexi films were made using this biopolymer, dextrose as a flexicizer, and sween 80 as a permeation enhancer.

The weight uniformity, medication content, folding endurance, and thickness of the formulations were all measured. To quantify the amount of risperidone contained in the patches, in vitro dissolution of the experimental formulations was performed, and scanning electron microscopy of the produced bioflexi films was taken to examine the drug distribution pattern. The Fourier transform infrared spectroscopy technique was used to study drug-excipient interactions. In vitro dissolution investigations revealed that drug distribution in the bioflexi film was homogeneous, and that the maximal drug release in 24 hours with formulation EF3 was 99.81 percent. A modified Franz’s diffusion cell was used to conduct an in vitro skin permeation research, which revealed that the maximum penetration with the formulation EF3 was 768.50 g/cm2 after 24 hours.

Conclusion: Optimized formulations were determined to be suitable for formulation in terms of physicochemical properties, and no significant interaction between the medicine and the biopolymer utilised was observed.

Author (S) Details

Bhavana Singh
School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun, Uttarakhand, India.

N. V. S. Madhav
Vital Therapeutics and Formulation Pvt. Ltd. Secunderband, Telangana, India.

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