Advanced Study on Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate Cements

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Advanced Study on Preparation, Physical-Chemical Characterization, and Cytocompatibility of Polymeric Calcium Phosphate Cements

November 18, 2020 Medicine and Medical Science 0

Background: Much attention has recently been paid to calcium phosphate cements (CPCs) because of their advantages in terms of in situ handling and forming capabilities compared to calcium phosphate bioceramics. Mechanical and in vitro biological physicochemical properties of novel polymeric calcium phosphate cement (CPC) formulations have been investigated.
Methods: to obtain Forms I, II and III CPCs, monocalcium phosphate, calcium oxide and synthetic hydroxyapatite were mixed either with modified polyacrylic acid, light activated polyalkenoic acid or with polymethyl vinyl ether maleic acid. CPCs were compared with zinc polycarboxylate cement (control) setting time, compressive and diametric strength. X-ray diffraction, scanning electron microscopy, and infrared spectroscopy were used to identify specimens. CPCs and control were tested for in vitro cytotoxicity.
Results: Hydroxyapatite, monetite, and brushite were seen by X-ray diffraction analysis. The presence of stretching peaks in the IR spectra of set cements confirmed the acid-base reaction. Rod-like crystals and platy crystals were disclosed by SEM. The cement setting time was 5-12 min. Compared with power, type III showed significantly higher strength values. High biocompatibility was achieved in type III.
Conclusions: In comparison to zinc polycarboxylate cement (control group), Type III CPC displayed acceptable setting time, substantially higher compressive, and diametral tensile strengths. For dental applications, Type III CPCs show promise.

Author(s) Details

Rania M. Khashaba
Department Oral Biology, Medical College of Georgia, Augusta, GA 30912-1129, USA., Department Orthopaedic Surgery, Section of Biomaterials, Medical College of Georgia, Augusta, GA 30912-1129, USA. and Department of Dental Materials, Misr International University (MIU), Cairo 11787, Egypt.

Mervet Moussa
Department of Oral Pathology, Cairo University, Cairo 11559, Egypt. and Department of Oral Pathology, Misr International University (MIU), Cairo 11787, Egypt.

Christopher Koch
Department Orthopaedic Surgery, Section of Biomaterials, Medical College of Georgia, Augusta, GA 30912-1129, USA.

Arthur R. Jurgensen
Savannah River National Laboratory, Savannah River Nuclear Solutions, Aiken, SC 29808, USA.

David M. Missimer
Savannah River National Laboratory, Savannah River Nuclear Solutions, Aiken, SC 29808, USA.

Ronny L. Rutherford
Savannah River National Laboratory, Savannah River Nuclear Solutions, Aiken, SC 29808, USA.

Norman B. Chutkan
Department Orthopaedic Surgery, Section of Biomaterials, Medical College of Georgia, Augusta, GA 30912-1129, USA.

James L. Borke
Department Oral Biology, Medical College of Georgia, Augusta, GA 30912-1129, USA and Department Orthopaedic Surgery, Section of Biomaterials, Medical College of Georgia, Augusta, GA 30912-1129, USA.

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