Allium cepa Linn Improved Rhodanese Activity and Half-life of Cyanide in the Blood
Rhodanese is an intramitochondrial liver enzyme responsible for cyanide detoxification. Allium cepa (Onion); an organosulphur-rich plant that may provide sulphur for cyanide detoxification. The effects of Allium cepa on rhodanese activity during cyanide toxicity were studied in male Wistar rats in vitro and in vivo. In vivo experiments were conducted to investigate the effects of methanol extract of onion (MEAC) and sodium thiosulphate (Na2S2O3) on rhodanese activity, urine thiocyanate concentration, and the effects of MEAC, raw onion, and Na2S2O3 on potassium cyanide half-life (KCN). Experiments in vitro looked into the MEAC and onion essential oil have been shown to inhibit rhodanese activity in liver cells. The in vivo study found that administering Na2S2O3 to the cyanide-treated group increased rhodanese activity, whereas the extract did not. The in vitro study found that onion essential oil increased rhodanese activity by ten times that of the extract. When raw onion consumption was compared to control, the half-life of KCN was significantly lower (p0.05). The findings suggest that Allium cepa improves cyanide detoxification by increasing rhodanese enzyme activity and decreasing cyanide half-life in the blood.
Author (S) Details
Dr. Fausat Kikelomo Ola-Mudathir
Department of Physical and Chemical Sciences, Elizade University, Ilara-Mokin, Ondo State, Nigeria.
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