An Experimental Rat Model of Acute Pancreatitis and the Effect of Apigenin

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An Experimental Rat Model of Acute Pancreatitis and the Effect of Apigenin

June 23, 2022 Medical Science 0

By assessing the levels of interleukin-6 (IL-6), interleukin-18 (IL-18), resistin (R), and CD45 in blood and high mobility group box 1 protein (HMGB1) in intestinal tissue using a rat experimental model, the study’s goal was to determine the impact of apigenin (AP) on acute pancreatitis (ACP). We employed 126 male Wistar rats and put them into three groups: Apigenin (A), Control (C), and Sham (S) (Ap). The abdominal wall was closed and a laparotomy was performed on the S group. The pancreatic duct was severed to cause acute pancreatitis in the C group. After ACP was introduced, AP was given to the apigenin group. We gathered blood and intestinal tissue. Following AP delivery, intestinal tissue levels of HMGB1 and CD45 as well as IL-6 and IL-18 in the blood were reduced. R, however, continued to be at low levels in the Ap group. In an animal model of bilio-pancreatic duct ligation, AP therapy appears to preserve serum and intestinal parameters, reducing the severity of ACP. Giving this material to people might thus lessen the harm done to the organs that are afflicted in the early stages of ACP.

Author(s) Details:

Sovatzidis Apostolos,
Faculty of Medicine, Democritus University of Thrace, Alexandoupolis, 68100-Greece.

Oikonomou Panagoula,
Faculty of Medicine, Democritus University of Thrace, Alexandoupolis, 68100-Greece and  Department of Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis-68100 Greece.

Nikolaidou Eirini,
Department of Plastic, Reconstructive and Hand Surgery & Burns ICU, General Hospital of Thessaloniki “G. Papanikolaou”, Thessaloniki, 57010-Greece.

Lambropoulou Maria,
Laboratory of Histology and Embryology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, 68100-Greece.

Papachristou Fotini,
Laboratory of Experimental Surgery and Surgical Research, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, 68100-Greece.

Papalois Apostolos,
Educational and Research Center ELPEN, 19009- Greece.

Tsalikidis Christos,
Faculty of Medicine, Democritus University of Thrace, Alexandoupolis, 68100-Greece and Department of Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis-68100 Greece.

Tsaroucha K. Alexandra,
Faculty of Medicine, Democritus University of Thrace, Alexandoupolis, 68100-Greece and Department of Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis-68100 Greece and Laboratory of Experimental Surgery and Surgical Research, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, 68100-Greece.

Please see the link here: https://stm.bookpi.org/NHMMR-V11/article/view/7145

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