Antibiotics Impact on Mitochondria Result in Potential Contributions to Carcinogenesis, Coronary pathology, other Medical Conditions and Ecosystem Risks
Calghatgi’s discovery that three popular antibiotics (Abs) enhanced mitochondrial reactive oxygen (ROS) and lipid peroxide (LP) while depleting their natural absorbant glutathione prompted me to look into the potential carcinogenic effects of these genotoxic chemicals. Antibiotics had a wide spectrum of effects on mitochondria and cellular DNA, all of which were consistent with previous contributions to carcinogenesis. HCC, RCC (KCC), CRC, and esophageal cancers were all likely to have grown as a result of these modifications. In this sense, LP-induced tumour suppressor gene alterations were remarkable, and mutations produced in CRC were consistent with those observed in carcinogenesi. This suppresses the immune system and raises the risk of cancer in general. Many cancers have been linked to heightened odds ratios in epidemiological research, with deadly breast cancer being one of the most concerning. The impact of mitochondrial dysfunction was also connected to a depression of the citric acid cycle and therefore ATP, which shifted metabolism to glycolysis, the Warburg mechanism, increasing the risk of all malignancies, which is favoured by cancer cells. To summarise, the number, type, and frequency of Abs treatments, as well as chronic residue exposure, all of which vary from person to person, are likely to raise the risk of several cancer types. This prompted me to Abs has a three-pronged carcinogenesis mechanism, according to the researchers. 1. Critical cancer mutations 2. Immune deficiency 3. Warburg effects are caused by a decrease of mitochondrial functioning. Common pesticides studied in China and more recently by covid spike protein  caused damage to mitochondria, and many pesticides were linked to cancer, implying a similar contributing aetiology. Because of the many mitochondria in the heart and the necessity for long-term reliability, these discoveries have raised worries about heart health. There were studies given that suggested Abs and pesticide exposure had an effect on the heart. Because of their ubiquity in terms of geography and the size of the population, Biodiversity and life in general are threatened by a variety of disorders linked to mitochondrial malfunction, antibiotics and insecticides, and bacteriacidal biocides. I offer research steps for evaluating antibiotic safety, as well as future research directions and suggestions for techniques to reduce Abs toxicity.
Ubc Zoology Grad and Sfu Educ Alumni, Canada.
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antibiotic. cancer Carcinogenesis cell perforation cell rupture clastogenic DNA DNA damage dysbiosis epigenetic silencing glycolysis heart immune suppression lipid peroxide mechanism. microbiome microRNA Mitochondria mutp53 oxidative phosphorylation P53 tumor suppressor gene pesticides ROS Warburg effect