Autologous Platelet Derived Growth Factor and Fibrin Rich Plasma in Chronic Non-healing Ulcer

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Autologous Platelet Derived Growth Factor and Fibrin Rich Plasma in Chronic Non-healing Ulcer

August 19, 2021 Medicine and Medical Science 0

Background and Goals: Infections, trauma, or underlying medical or surgical disorders can cause a chronic non-healing ulcer (CNHU). Ulcers that have not responded to all known treatment options over an extended period of time are more likely to develop gangrene and infection, which can lead to limb amputation. This is a serious public health issue. None of the standard treatments are expected to promote active wound healing. The effectiveness of topically applied autologous platelet-derived growth factors and fibrin-rich plasma in the active repair of chronic non-healing ulcers has been extensively researched. Its efficacy in speeding the inflammation, tissue proliferation, angiogenesis, and remodelling stages of early wound healing and repair has been demonstrated in studies. PDGF is important for attracting inflammatory cells to the wound site, as well as increasing their release of growth factors, chemotactic factors, and cell migration. Various signalling transduction pathways cause different effects in different cells. The efficacy of topically applied autologous platelet generated growth factors and fibrin rich plasma in the treatment of chronic non-healing ulcers has been demonstrated in numerous investigations. Future research is needed to pinpoint the numerous signalling mechanisms at distinct stages of wound healing.

Author (S) Details

Suprava Patel
Department of Biochemistry, All India Institute of Medical Sciences, Raipur, C.G, India.

Piyush Bhargava
Department of Biochemistry, Pt. J.N.M. Medical College, Raipur, C.G, India.

V. Jain
Department of Orthopedics, Pt. J.N.M. Medical College, Raipur, C.G, India.

O. P. Tucker
Visiting Consultant, Stem Cell Lab, Pt. J.N.M. Medical College, Raipur, C.G, India.

P. K. Khodiar
Department of Biochemistry, Pt. J.N.M. Medical College, Raipur, C.G, India.

P. K. Patra
Department of Biochemistry, Pt. J.N.M. Medical College, Raipur, C.G, India.

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