Brain Derived Neurotrophic Factor (BDNF) As a Predictive Biomarker of the Occurrence of Post Traumatic Stress Disorder (PTSD)
Over the course of three months, the major purpose of the pilot study was to evaluate the rate of serum BDNF and the initial clinical course of a participant who had been exposed to a potentially traumatic experience. In this study, 12 participants were recruited, 7 of whom had been exposed to a traumatic event and 5 of whom had no history of psycho-trauma. There is no link between cortisol levels in the blood and BDNF levels in this investigation. The following are the study’s findings: The rate of BDNF in the trauma group of volunteers was significantly lower than in the control group:
6.201.73 ng/ml in the trauma group against 21.791.76 ng/ml in the control group, indicating a p0.001 difference. When compared to those who have been through a traumatic incident, the rate of serum BDNF in victims of physical aggression is significantly lower: With a p = 0.03 difference, the assault group received 4.360.37 ng/ml while the control group received 6.941.44 ng/ml. The intensity of peritraumatic discomfort is significantly inversely linked with the amount of BDNF (r = -0.75, p0.05). The rate of serum BDNF was considerably decreased in the group with acute PTSD as compared to the group without PTSD: p = 0.001 between 7.50.9 ng/ml in the absence of PTSD (n = 4) and 4.50.4 in the presence of PTSD (n = 3).
Author (s) Details
Dr. H. Belhadj-Tahar
Mental health research group, French Association for Medical Research Advancement (AFPREMED), 9 rue du Pr Antoine Baisset, 31000 Toulouse, France.
Dr. N. Sadeg
International Medical Institute of Toxicology and Pharmacology, Bat. B8, Rue Henri Becquerel, 60230 Chambly, France.
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