Brain Derived Neurotrophic Factor (BDNF) As a Predictive Biomarker of the Occurrence of Post Traumatic Stress Disorder (PTSD)

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Brain Derived Neurotrophic Factor (BDNF) As a Predictive Biomarker of the Occurrence of Post Traumatic Stress Disorder (PTSD)

June 2, 2021 Medicine and Medical 0

Over the course of three months, the major purpose of the pilot study was to evaluate the rate of serum BDNF and the initial clinical course of a participant who had been exposed to a potentially traumatic experience. In this study, 12 participants were recruited, 7 of whom had been exposed to a traumatic event and 5 of whom had no history of psycho-trauma. There is no link between cortisol levels in the blood and BDNF levels in this investigation. The following are the study’s findings: The rate of BDNF in the trauma group of volunteers was significantly lower than in the control group:
6.201.73 ng/ml in the trauma group against 21.791.76 ng/ml in the control group, indicating a p0.001 difference. When compared to those who have been through a traumatic incident, the rate of serum BDNF in victims of physical aggression is significantly lower: With a p = 0.03 difference, the assault group received 4.360.37 ng/ml while the control group received 6.941.44 ng/ml. The intensity of peritraumatic discomfort is significantly inversely linked with the amount of BDNF (r = -0.75, p0.05). The rate of serum BDNF was considerably decreased in the group with acute PTSD as compared to the group without PTSD: p = 0.001 between 7.50.9 ng/ml in the absence of PTSD (n = 4) and 4.50.4 in the presence of PTSD (n = 3).

Author (s) Details

Dr. H. Belhadj-Tahar
Mental health research group, French Association for Medical Research Advancement (AFPREMED), 9 rue du Pr Antoine Baisset, 31000 Toulouse, France.

Dr. N. Sadeg
International Medical Institute of Toxicology and Pharmacology, Bat. B8, Rue Henri Becquerel, 60230 Chambly, France.

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