Category: Chemistry and Biochemistry

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Synthesis, Characterization and Biological Activities of Schiff Bases and Their Transition Metal Complexes

Schiff bases are versatile ligands that are generated by combining primary amines with carbonyl groups. Because of their broad range of biological activities, these compounds are extremely significant in the medical and pharmaceutical fields. The majority of them have biological properties such as antibacterial, antifungal, and antitumor properties. Transition metal complexes with biological activity derived…
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March 13, 2021 0

Analysing the Impact of Nutritional and Environmental Epigenetics on Human Health and Disease

Environmental epigenetics is the study of how environmental factors influence cellular epigenetics and, as a result, human health. To control gene expression, epigenetic marks change the spatial conformation of chromatin. Behaviours, diet, and contaminants and industrial toxins are all environmental factors that have epigenetic implications. Environmental exposures can damage the foetus by impairing the epigenome…
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March 13, 2021 0

Study on Proteomic Profiling of High-grade Glioblastoma: Aspects of Biomarkers

Using two-dimensional electrophoresis (2DE), mass spectrometry (ESI LC-MS/MS), and immunodetection, researchers were able to identify and quantify different proteoforms (protein species) present in a cell line derived from a high-grade glioblastoma cell line. It was possible to obtain a 2DE protein map with a large data set of 937 spots and 1542 separate protein identifications…
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March 13, 2021 0

Distribution of Proteoforms Numbers in a Human Cell according to Their Abundance is Following Zipf’s Law

The complex functional mechanisms of the cellular proteome are provided by the collaboration of thousands of protein components, protein species/proteoforms. Although recent methods do not yet enable us to obtain a complete picture of this collaboration, they do allow us to create a description of the proteome size and quantitative distribution of proteoforms within the…
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March 13, 2021 0

Recent Study on Copper-Promoted One-Pot Approach: Synthesis of Benzimidazoles

For the production of various 2-arylaminobenzimidazoles, a simple, one-pot method was produced. For the first time, a copper catalyst promoted domino C–N cross-coupling reaction for the generation of 2-arylaminobenzimidazoles is used in this process. The synthetic pathway involves a copper-based desulphurization/ nucleophilic substitution followed by domino intra and intermolecular C–N cross-coupling reactions, according to mechanistic…
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March 13, 2021 0

Potential Anti-diabetic Activities from Edible Bird Nest and Its Hydrolysates

Edible bird’s nest (EBN) is traditionally regarded as a delicacy, with numerous health benefits believed to be sought after in Asia, especially China. The anti-diabetic properties of the EBN and its hydrolysate were discussed in this paper. L6 myotube cells were used to test the ability of EBN hydrolysate to promote glucose absorption in vitro.…
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March 13, 2021 0

Discussion on the Possible Role of Molecular Vibration in Intracellular Signalling

The knowledge exchange inside the cell is extremely complicated. Physical signalling is expected to fulfil spatial and temporal aspects in addition to the well-studied chemical signalling. For several intracellular transport functions, the Golgi apparatus and the microtubule skeleton system are critical structures. The well-directed placement of structural elements requires close contact between the Golgi apparatus…
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March 13, 2021 0

An In-vitro and In-vivo Study of Antioxidant Potential of Green Synthesized Flavonoid Loaded Mono and Bimetallic Nanoparticles

Nanotechnology’s remarkable performance has unwrapped the vision for creating mono and multimetallic nanoparticles with a wide variety of applications due to their distinct conduct. Gold and silver nanoparticles have made considerable strides in biomedical science, in particular. The study uses flavonoids extracted from the bark of the Madhuca longifolia plant to fabricate mono (Au, Ag)…
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March 13, 2021 0

Microwave Assisted Reactions for Synthesis of Bioactive Azaheterocycles

Azaheterocycles have gotten a lot of attention in recent years because of their common occurrence in many natural and synthetic products, as well as their wide range of biological activities. Simultaneously, greener and more environmentally sustainable synthetic approaches are urgently needed to meet the changing demands of the world. In this context, developing more efficient…
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March 13, 2021 0

Recent Approach on Determination of Impurities and Degradation Products/Causes for m-Iodobenzylguanidine Using HPLC-Tandem Mass Spectrometry

m-Iodobenzylguanidine hemisulfate  (MIBGHS) is a precursor for radioiodine-labeled m-iodobenzylguanidine (MIBG), which is used as a radio-imaging and therapy agent for neuroendocrine tumours and myocardial sympathetic nerve activity. The purity of the precursor, source of impurity, and derivatives must all be calculated in order to ensure the medicine’s consistency and effectiveness while avoiding side effects. The…
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March 13, 2021 0