The purpose of this monograph is to provide an extensive review of the drug Flupirtine clinical applications and its safety-related issues. While existing Non- Steroidal Anti-inflammatory Drugs (NSAIDs) and Opioids which are used in the treatment of pain had some common adverse effects this drug is devoid of adverse effects exhibited by NSAIDs and Opioids…
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Background: from 1993 until 2013 our Emergency Department (ED) went through three periods, with different ED manager each. Although the number of beds, visits and admissions during these three periods didn’t change significantly, a change in the ED’s policy, without a change in the hospital’s policy, converted a very crowded ED to a non-crowded one…
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Introduction: Fractures and dislocations are a significant public health and economic burden but the epidemiology of fracture dislocations is poorly understood. This study aimed to evaluate the prevalence and distribution of various fracture dislocations. Materials and Methods: Fracture dislocation cases who underwent closed reduction by a general surgeon where no Orthopaedician was available were recorded.…
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This article aims to present a modified yet simple technique for the placement of implants between the mandibular foramina with the help of a radiographic stent. A radiographic stent was made on the patient’s mandibular cast on which two metal balls were fixed at the premolar area and this was then used to determine the…
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Objective: Our objective is to show the superiority of the membrane selection and connected energy dose fixed via personal sensing. Method: Hyperthermia in oncology involves heating malignant cells and causing thermal damage in an attempt to destroy them. This could be immediate (necrotic) cell-distortion and ignite natural cell elimination, like apoptosis or autophagy. Two concepts…
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Objective: This work investigated the In vitro and In vivo anti Helicobacter pylori activity, and the healing and antisecretory effects of the aqueous extract of Eremomastax speciosa on “unhealed gastric ulcers” associated with gastric acid hypersecretion. Materials and Methods: H. pylori isolates were obtained from gastric biopsies collected in the Civil hospital, Karachi. In vitro…
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Lichenoid skin disorders are a group of dermatological manifestations associated with flat topped itchy and scaly skin. These are also well known as drug induced lichen planus and are result of cutaneous adverse effects by most drugs. Offending agents involved in the lichenoid disorders are Antimalarial, Antidiuretics, Antihypertensive and Non-Steroidal Anti- inflammatory drugs (NSAIDs) etc.…
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Angiogenesis is the formation of new blood vessels from preexisting vasculature, being mediated and regulated by a complex composed of growth factors, cytokines, cell signaling molecules and extracellular matrix components. The most important pro-angiogenesis regulator molecules are vascular endothelial factor (VEGF), fibroblasts growth factors (FGFs), hypoxia-inducible factor 1 (HIF- 1), platelet-derived growth factor (PDGF) and…
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Morbidity and mortality from heart failure is on the increase globally due to rising prevalence rates and lack of appropriate evaluation and therapy. Approximately 50% of heart failure patients present with evidence of left ventricular systolic dysfunction. This is manifested as low left ventricular ejection fraction and is also called Heart failure with reduced ejection…
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A 74-year-old Japanese housewife was shown to have a large, smooth-surfaced, protruding, semipedunculated tumor covered with the normal-appearing mucosa on the posteromedial wall of the mid descending part of the duodenum immediately oral to the papilla of Vater by endoscopy. ERCP demonstrated the normal main and accessory pancreatic ducts. Just after abruptly contracted, the terminal…
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