Category: Pharmaceutical

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Determining the Anti-Inflammatory and Anti-Microbial Activity of Chalcone from Dalbergia sissoo Roxb. Leaves

The isolation and characterization of a chalcone or okanin [(E)-3-(3,4-dihydroxyphenyl)-1-(2,3,4-trihydroxyphenyl) prop-2-en-1-one] has been disclosed in this paper. Bio-assay-guided fractionation was used to isolate the cells. Methanol, hexane extracts, and isolated okanin from methanol extracts all had antibacterial action against gramme positive (Micrococcus luteus and Staphlococcus aureus) and gramme negative bacteria (Escherichia coli, R. planticola and…
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December 20, 2021 0

Determination of Gastrointestinal Toxicity of Selective COX-2 Inhibitors in Comparison with Conventional NSAIDs

Background: The most prevalent side effects of NSAIDs are adverse gastrointestinal events, which are thought to be caused by the suppression of gastric COX-1, which is responsible for the manufacture of prostaglandins that typically regulate acid secretion and protect the mucosa. According to previous research, selective COX-2 inhibitors are safer than non-selective cyclooxygenase inhibitors when…
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December 20, 2021 0

Scientific Investigation of Dyschoriste littoralis nees – A Tamil Traditional Medicinal Plant against Liver Disease

The goal of this study was to see if Dyschoriste littoralis Nees (family Acanthaceae) might protect rats’ livers against paracetamol-induced hepatotoxicity. The aerial portions of Dyschoriste littoralis Nees. powder were extracted using a Soxhlet extractor with various solvents (PE, EA, and methanol) and crude varied extracts were used for hepatoprotective activities. All of the extracts…
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December 20, 2021 0

Determination of Improved Efficacy and Stability of Silymarin Loaded Nanocochleates Over Liposomes for the Treatment of Skin Diseases

Aim: The anti-oxidant, anti-inflammatory, and membrane-stabilizing properties of silymarin, a complex polyphenolic component mixture, are being studied in a variety of dermatological disorders. The goal of this study is to see if silymarin-loaded nanocochleates and liposomal topical treatment can help with chronic skin conditions. The purpose of this study was to create and assess Silymarin-loaded…
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December 20, 2021 0

Recent Advancements on Callus and Cell Suspension Cultures: An Effectual Reserve for the Production of Pharmaceutically Significant Metabolites

Alkaloids, glycosides, flavonoids, volatile oils, tannins, resins, and other phytopharmaceuticals are examples of secondary metabolites of pharmaceutical significance. Because their chemical synthesis is either extremely difficult or economically impractical, the majority of these secondary metabolites are currently isolated from wild or cultivated plants. Although production by callus and cell suspension cultures is a lovely alternative,…
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December 20, 2021 0

Evaluation and Pharmacological Screening of Endophytic fractions of Centella asiatica Linn Leaves for In-vitro Antioxidant Activity

We isolated fungal endophytes from Centella asiatica Linn leaves, then fermented and extracted the endophytes with non-polar solvents such as chloroform, ethyl acetate, and n-butanol. An invitro free radical scavenging activity experiment using reducing power, DPPH, and hydroxyl radical assays was followed by a preliminary phytochemical examination of endophytic crude extracts of leaves to evaluate…
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December 20, 2021 0

Energy-Saving Pre-Gelatinization of Arthocarpus altilis Fruits Starch and Evaluation as Disintegrant in Oral Paracetamol Tablets

Natural polymers have been modified to give them desirable qualities, making them acceptable for use as medicinal additions. The goal of this project was to use acetone to make pre-gelatinized breadfruit starch, which would save drying time and energy consumption. In paracetamol oral compacts, the modified starch was tested as a disintegrant. The way disintegrants…
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December 20, 2021 0

Determination of Pharmacological and Therapeutic Potential of Cissus quadrangularis L.

The goal of this study was to find out how effective Cissus quadrangularis is as a pharmacological and therapeutic agent. L. Cissus quadrangularis(CQ) Linn., also known as Veldt Grape, Winged Tree-bine, or Devil’s Backbone, is an Asian and African plant that is endemic to India and Sri Lanka. Numerous studies support the creation of new…
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December 20, 2021 0

Biological Profile and Therapeutic Potentials of Cardiospermum halicacabum (Sapindaceae)

The goal of this study was to find out more about Cardiospermum halicacabum’s biological profile and therapeutic potential. The whole plant has been used to treat rheumatism, stiffness of limbs, and snakebites. Cardiospermum halicacabum is an annual or perennial herb that is often encountered in Sri Lanka. Gastrointestinal difficulties, respiratory disorders, and urinogenital infections have…
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December 20, 2021 0

A Compendium of Precision Oncology: An Approach towards Unveiling the Unique and Individualized Reality of Cancer

The employment of a “one size fits all” strategy, that is, a comparable line of therapy or the use of the same drug/medicine, that too in a conventional method, to cure a certain condition, has been witnessed for several decades. Rather than specific human characteristics, this strategy is linked to unique genetic constitutions and processes.…
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December 20, 2021 0