Category: Pharmaceutical

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Synthesis and Spectral Studies on New Meso-Substituted Unsymmetrical Porphyrins

Three new meso-functionlized unsymmetrical porphyrins have been synthesised and characterised. UV-visible, IR, 1H NMR, mass, spectra, and elemental analysis were used to determine the structural assignment of these porphyrins. The current correspondence discusses a novel approach for the synthesis of porphyrins that differs from Adler’s general synthetic technique. Meso-substituted porphyrins with complex functional group patterns…
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March 11, 2021 0

Flavonol Glycosides from the Aerial Parts of Indigofera hirsuta and Anti-inflammatory Activity of n-butanol Fraction

Aims : The aim of this study was to investigate the phytochemical properties of the n-butanol soluble fraction of Indigofera hirsuta aerial parts and to assess the fraction’s anti-inflammatory behaviour using laboratory animal models. Study Design: Isolation and elucidation of bioactive substances, as well as anti-inflammatory activity testing on the soluble fraction of n-butanol. Place…
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March 11, 2021 0

Effects of CTHepaB, a Traditional Vietnamese Medicinal Formulation, on the Treatment of Cirrhosis in Wistar Rats

Objectives: CTHepaB is a popular Vietnamese herbal formulation that is used to avoid liver problems. In this analysis, the effects of CTHepaB on cirrhosis in Wistar rats caused by carbon tetrachloride (CCl4) combined with alcohol, high-fat, and iron diet were evaluated in vivo. Materials and Methods : Cirrhosis was induced in Wistar rats by injecting…
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March 11, 2021 0

Direct and Off-Target Effects of ATP-Sensitive Potassium Channels Opener Diazoxide: A 2020 Update

Diazoxide (DZ) is a well-known cardioprotective drug that works in the same way as ischemic preconditioning. DZ is primarily a pharmacological opener of mitochondrial ATP-sensitive potassium channels (mKATP channels), but its interactions with other cellular targets (such as plasma membrane KATP channels, F0F1 ATP synthase, succinate dehydrogenase, and others) are known to cause several side…
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March 11, 2021 0

Wild Grape Fruits Extracted by Different Solvents: Phytochemicals and Biological Activities

The aim of this study was to look into the phytochemical, antioxidant, and antibacterial activities of different coloured wild grape fruits extracted with different solvents such as water, methanol, and ethanol. Folin-Ciocalteu and colorimetric aluminium chloride assays were used to assess total phenolic (TPC) and flavonoid (TFC) content, while 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant…
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March 11, 2021 0

Efficacy or Exaggeration – Monitoring the Likely Role of Evefresh Cream for SLE

The current thesis examines the photoprotective properties of Evefresh cream. To provide consumers with sun protection, the personal care industry is actively competing and crowding the market with a wide range of sun screeners and SPF products. To investigate the cream’s influence, we used cyanotype paper, which is both fast and sensitive. The results indicate…
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March 11, 2021 0

Genotoxic Effect of Inorganic Arsenic Compounds Using Comet Assay

Background: Arsenic is a toxicological threat in the environment today since it has been shown to be a human genotoxin and carcinogen. Aim : The aim of this study was to determine the genotoxic effect of the four arsenic compounds in HepG2 cells by measuring DNA damage, cellular glutathione (GSH) depletion as a measure of…
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March 11, 2021 0

Reporting a Case of False-positive Radio-iodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor

123-Metaiodobenzylguanidine (MIBG) scintigraphy is a commonly used functional imaging technique for diagnosing pheochromocytoma with a high degree of sensitivity and specificity. However, there have been a few reports of false positive reactions. A 67-year-old man was admitted to the hospital with epigastric pain. Following hormone monitoring, 123I-MIBG scintigraphy was performed to assess the existence of…
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March 11, 2021 0

An in-vitro Bactericidal Efficacy of Ocimum tenuiflorum (Tulsi), a Known Indian Folk Medicinal Plant

Traditional medicine has used medicinal plants to treat diseases caused by microorganisms because they contain therapeutic components. The phytochemical analysis of ethanol, methanol, acetone, and aqueous extracts of Ocimum tenuiflorum, as well as its antibacterial activities, were investigated in this review. Shade dried leaves of Ocimum tenuiflorum were powdered and extracted with ethanol, methanol, acetone,…
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March 11, 2021 0