Clinical Features of Rhinosporidiosis in the Endemic Areas of Brazil

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Clinical Features of Rhinosporidiosis in the Endemic Areas of Brazil

July 1, 2020 Medical Science 0

Background: Rhinosporidiosis is a rare chronic disease caused by Rhinosporidium seeberi, mainly affecting the nasal and conjunctival mucosa. The diagnosis is made through histopathological examination. The disease is endemic to the Indian subcontinent, with few cases described in Brazil. Thus, this study aimed to describe clinical and histopathological aspects of rhinosporidiosis in an area of northeastern, Brazil.  Methods: To identify the clinical and histopathological characteristics, a retrospective study was carried out on 21 patients diagnosed with rhinosporidiosis at the Presidente Dutra University Hospital during 10 years. The data are obtained from medical records and review of histological slides of each case.  Results: In this study, most of the patients were men (80.00%), aging between the first and second decade of life, and with an infection in the nasal cavity (85.71%). Their main complaints were nonspecific, such as foreign body sensation, nasal obstruction and epistaxis, which decreased clinical suspicion (14.28%). Hemograms showed a high eosinophil count (14.01%, ±13.73). The main morphological alterations found in histopathological analysis were squamous metaplasia, mucosal hyperplasia, vascular ectasia, and inflammatory infiltration.  Conclusions: In our country, little is known about the pathogenesis of rhinosporidiosis, and it is easily confused with other pathologies. However, our cases have shown a series of morphological alterations that can be helpful to histopathological diagnosis and are poorly described in the literature.

Author (s) Details

Antonio Augusto
Postgraduate Program in Adult Health (PPGSAD), Federal University of Maranhão, São Luís, Maranhão, Brazil.

Francílio Araújo Almeida,
Laboratory of Immunofluorescence and Electron Microcopy (LIME), Presidente Dutra University Hospital, Federal University of Maranhão, São Luís, Maranhão, Brazil.

José de Ribamar Castro Veloso,
Department of  Pathology, Presidente Dutra University Hospital, Federal University of Maranhão, São Luís, Maranhão, Brazil.

Jaqueline Diniz Pinho,
Laboratory of Immunofluorescence and Electron Microcopy (LIME), Presidente Dutra University Hospital, Federal University of Maranhão, São Luís, Maranhão, Brazil.

Antonio de Deus Filho,

Federal University of Piauí, Teresina, Piauí, Brazil.

Joyce Santos Lages,
Department of  Public Health, Presidente Dutra University Hospital, Federal University of Maranhão, São Luís, Maranhão, Brazil.

Gyl Eanes Barros Silva,
Department of Pathology, Ribeirão Preto Medical School – University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

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