Clinical Genomic Analysis and Diagnosis – An Ex vivo, In vitro, and In silico Approach

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Clinical Genomic Analysis and Diagnosis – An Ex vivo, In vitro, and In silico Approach

August 3, 2022 Medical Science 0

It has been seventeen years since the publication of single-cell genomic analysis, a systematic overview of single-cell approaches integrating genomic and proteomic investigations. Molecular pathology, molecular genetics, forensic medicine, and biomarker discovery have all benefited from the application of single-cell techniques with downstream genomic and proteomic analyses. Additionally, the dynamic cell-sorting method has made significant strides in the therapeutic domains of cancer stem cell differentiation, regeneration medicine, and downstream cell culture and genetic research of stem cells. Furthermore, advanced cancer illness has been treated using tissue level sampling and in silico analysis. Physicians and scientists can now use one of these techniques with genomic analysis in their clinical areas of research thanks to recent developments in homogeneous cell sorting in vitro (or single cells technique), ex vivo (dynamic analysis or small number of cell cultures with downstream genomic analysis), and in silico (tissue level sampling with in silico analysis). In order to fully understand these contemporary procedures, this manual will explain recently established techniques of clinical genomic analysis in vitro, in silico, and ex vivo. The author of the review study also goes through how to use these techniques in various clinical settings. Some of the problems that mixed cells from clinical specimens provide for clinical genomics analysis and diagnosis will eventually be addressed in the manual.

Author(s) Details:

Biaoru Li,
Department Pediatrics, Georgia Cancer Center, MCG, Augusta, GA 30912, Georgia.

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Keywords: Genomics analysis, clinical genomics diagnosis, single-cell diagnosis, single-cell genomics analysis and diagnosis, primary cell culture, biomarker discovery, therapeutic targeting


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