Correction of Chronic Hypoxia and Apoptosis in Nephrotic Children
Objectives: To study the levels of cellular hypoxia, apoptosis and the dependence of these factors on the value of impaired kidney function; to assess the potential protective effects of tocopherol antioxidant therapy in children with nephrotic syndrome.
Context: Through the activation of certain secondary processes, hypoxia-related disorders play an important role in irreversible tissue damage. Peripheral edema, heavy proteinuria, and hypoalbuminemia, often with hyperlipidemia, consist of nephrotic syndrome (NS).
Methods: Renal biopsy screening of 53 patients (aged 10-15 years) with nephrotic syndrome. This study used conventional clinical studies, immunochemistry and immunoblotting.
Results: Children with nephrotic syndrome have been shown to have a high HIF-1 alpha cellular hypoxia marker. The latest levels depend on the level of impaired kidney function and proteinuria. The progression of sclerosis, which is a sign of irreversible kidney damage, is accompanied by a gradual increase in the expression of the proapoptotic factor Bax. A conventional system is composed of an applied treatment and tocopherol showed an improvement in the level of hypoxia, proapoptotic factor Bax expression.
Conclusion: The application of antioxidants can attenuate hypoxia-induced disorders in nephrotic children caused by disorders in the apoptosis control system. In the field of nephrology, further research into the molecular mechanisms that preserve the kidney in nephrotic children and non-toxic nephroprotective agents, including antioxidants, are important issues.
Author (s) Details
Department of Pediatrics №4, Bogomolets National Medical University, №4, Kyiv, Tolstogo Street 10, 01004, Ukraine.
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