Curcumin, Indomethacin, and Naproxen Synergistically inhibit the Growth of Human Colorectal Cancer Cells (HT-29): Current Research
The aim of this study was to investigate the effect of curcumin, indomethacin, curcumin and naproxen combination synergistically on the growth of HT-29 cells. The growth of HT-29 cells was examined by MTS cell viability assay by one to four days’ treatment with curcumin (10∼50 μM), indomethacin (250∼1,000 μM), curcumin (10∼50 μM) and naproxen (250∼1,000 μM) to 2×104 HT-29 cells/mL. The results suggested that curcumin inhibited the growth of HT-29 cells in a dose-dependent fashion. In concentration range from 500 to 1,000 μM, indomethacin inhibitied the growth of HT-29 cells in a dose-dependent fashion. To examine inhibitory administered or give of curcumin and indomethacin, curcumin and naproxen combinination on the HT-29 cell lines, we treatment with 20 μM curcumin and indomethacin (500 μM, 750 μM) combinination curcumin and naproxen (750 μM, 1,000 μM) combinination to 2×104 HT-29 cells/well. The results suggested that curcumin potentiates the inhibitory effect of indomethacin on the growth of HT-29 cell lines by shifting the dose-dependent manner.
Department of Pharmacology and Clinical Pharmacology Laboratory, College of Medicine, Hanyang University, Seoul 133-791, Korea.
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