Design, Synthesis and Biological Evaluation of Substituted StyrylIncorporated Quinazoline Derivatives as Anticancer Agents

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Design, Synthesis and Biological Evaluation of Substituted StyrylIncorporated Quinazoline Derivatives as Anticancer Agents

November 11, 2020 Chemical Science 0

A novel sequence of substituted aryl ethynyl integrated quinazolines (11a-j) were designed and synthesised and 1HNMR, 13CNMR, and mass spectral analysis characterised their structures. In addition, these compounds were tested against human cancer cell lines such as MCF-7 (human breast cancer), A549 (human lung cancer), DU-145 (human prostate cancer) and MDA MB-231 (human breast cancer) for their preliminary anticancer activity. Four compounds (11b, 11c, 11d and 11 g) were shown to have more potent activity of all compounds than etoposide.

Author(s) Details

Pruthu Kalaa
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh, 522510, India.

Dittakavi Ramachandrana
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Andhra Pradesh, 522510, India.

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