Determination of ctDNA, Targeted Therapies and Immunotherapy in Non-small-cell Lung Cancer

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Determination of ctDNA, Targeted Therapies and Immunotherapy in Non-small-cell Lung Cancer

September 8, 2021 Health Research 0

NSCLC, a kind of lung cancer, is one of the top causes of cancer death in both men and women around the world. From diagnostics to targeted NSCLC therapies, circulating tumour DNA (ctDNA), tyrosine kinase inhibitors (TKIs), and immunotherapy have revolutionised our understanding of NSCLC and its treatment. Quantifying ctDNA is simple and accurate, which makes clinical decisions easier. TKI-based targeted therapy and immunotherapy have also improved NSCLC patients’ quality of life. This article provides an overview of ctDNA technologies and their therapeutic applications. including TKIs such as osimertinib and lorlatinib that target the epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK), the emergence of various resistance mechanisms, the control of programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) by immune checkpoint inhibitors (ICIs) in Patients with NSCLC, on the other hand, have numerous challenges. More research and trials are needed to develop more effective drugs or therapies to treat NSCLC.

Author (S) Details

Chennianci Zhu
Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Weihao Zhuang
Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Limin Chen
Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Wenyu Yang
Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Wen-Bin Ou
Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.

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