Determining the Pancreatic Arginase Activity and α- Amylase Levels in Patients with Type 2 Diabetes and Alcoholic Pancreatitis
Arginase, a regenerative enzyme found in the endocrine pancreas, participates in insulin metabolism as well as regenerative processes during polyamine formation. High levels of -amylase have been linked to pancreatic damage. The purpose of this study was to see how arginase and -amylase functioned in the pancreas of people with type 2 diabetes and those who had alcohol-induced acute pancreatitis. Arginase and -amylase activities in pancreatic tissue were measured in patients with type 2 diabetes mellitus or acute pancreatitis without pancreatic diabetes. The results were compared to those of a control group. Our findings show that diabetic pancreas has higher arginase activity than controls, whereas pancreatitis tissues have lower arginase activity (P 0.05). The activity of a-amylase was higher in the pancreas of type 2 diabetes patients than in the pancreas of acute pancreatitis patients. Rather than being a source of damage mediators, increased arginase activity in type 2 diabetes patients may be associated with an effort to reclaim endocrine pancreatic function. Because pancreatitis causes acinar damage, resulting in the release of a-amylase, this enzyme was found to be higher in diabetic pancreatic tissue than in nondiabetic pancreatic tissue.
Author (S) Details
José D. Méndez
Medical Research Unit in Metabolic Diseases, Cardiology Hospital, National Medical Center, Mexican Institute of Social Security, México.
Roberto De Haro
Medicine Section, Iztacala Faculty, National Autonomous University of Mexico, Los Reyes Iztacala, Tlalnepantla, State of Mexico, 54090, Mexico.
General Hospital 49, Mexican Institute of Social Security, Los Moch, México.
Jorge L. Ble-Castillo
Research Station in DACS. Juárez Autonomous University of Tabasco, Avenida Gregorio Méndez 2890 Colonia Tamulte. 86100. Villahermosa, Tabasco, Mexico.
Hector O. Rubio
Faculty of Zootechnology and Ecology, Autonomous University of Chihuahua, Periferico Francisco R. Almada, Km 1, CP: 31453. Chihuahua, México.
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