Endometrial Cancer: Aberrations in Signaling Pathways and Targeted Intervention

Endometrial abnormal growth in animate being is ultimate low form of uterine cancer that has existed adjoining in addition four lakh cases occurring to the list of gynaecological cancers, accompanying extreme economic nations spiking up the pace. However, underdeveloped countries, containing India, further show a important number of cases. As this anomaly is guide overdone estrogen- corpulence, PCOD, estrogen-secreting tumors, menarche at an early age and end of menstrual cycle at a late age are few of the major risk determinants providing to allure cause. Changes at the historical level and run-down indicating pathways pave the way for the happening of endometrial tumor. Alterations in PI3K/PTEN/AKT road have happened involved primarily in TYPE I of endometrial malignancy, inasmuch as the main changed road being the reason for TYPE II is p53/p16 pathway, with remainder of something. Various situation procedures point or direct at a goal these particular indicating pathways are in different chapters of troubles, and few have proved hopeful results too. So, expanding address healings established particular microscopic pathways would aid in a good response rate and better forecast for endometrial malignancy victims.

Author(s) Details:

Ritu Yadav,
Department of Genetics, Maharshi Dayanand University, Rohtak (Haryana), 124001, India.

Parul Ahuja,
Department of Genetics, Maharshi Dayanand University, Rohtak (Haryana), 124001, India.

Nancy Lathwal,
Department of Genetics, Maharshi Dayanand University, Rohtak (Haryana), 124001, India.

Preeti Chauhan,
Department of Biotechnology, Chandigarh Group of Colleges, Landran, Mohali (Chandigarh); -140307, India.

Please see the link here: https://stm.bookpi.org/CAPR-V10/article/view/8796

Keywords: Endometrial cancer, PI3K/AKT/mTOR pathway, p53/p16 alteration, Wnt/β-catenin signaling pathway, HER2/neu alteration, targeted therapy