Enhancement of Antibacterial Activity of Turmeric Rhizome Extracts in Combination Treatment with Potassium Aluminium Sulphate
Using disc diffusion (DD) and agar well diffusion (AWD) protocols, the antibacterial ability of crude turmeric rhizome extracts in combination with Potassium aluminium sulphate (PAS / Alum) against four (4) bacterial species was calculated. All the test bacteria were sensitive to dose-dependent extracts with and without PAS. DD ‘s highest inhibition zone diameter (DIZ) was observed with ethanolic turmeric extract (ETE) in combination with PAS (ETE+PAS) at a concentration of 0.3 g on Escherichia coli (16.6±0.8 mm) and Pseudomonas fluorescens (15.3±1.1 mm) and Staphylococcus aureus (15.0±0.0 mm). PAS had the strongest operation with AWD at a concentration of 0.3 g on Bacillus cereus (17.8±1.0 mm), S. On P. fluorescens, as well as E. Whereas coli, ETE+PTA showed the highest antifungal activity on A. Terreus (35±1.0 mm), Crystallium of Penicillium and A. 33.0 mm (flavus) and S. Cerevisiae, respectively (24.0 mm). Additionally, the apparent demonstration of antibacterial activity by extracts of turmeric rhizome and potash alum on both Gram positive and Gram negative bacteria as well as against fungi is indicative of wide spectrum activity. However, on the other hand, the high activity of Ofloxacin (OFL) and Ketoconazole (KTA) against test microbes underlines their dominance with or without PTA / alum extracts. However, the increase in bioactivity of turmeric rhizome extracts was accentuated by the incorporation of potash alum, and such novel combinational approaches to research with healthy, natural materials will provide animals and human pathologies with reliable alternatives to synthetic antimicrobial chemotherapy.
Lawrence O. Amadi
Department of Microbiology, Faculty of Science, Rivers State University, P.M.B. 5080, Nkpolu-Oroworukwo, Port Harcourt, Nigeria and Department of Microbiology, School of Applied Science, Ken Saro-Wiwa Polytechnic, P.M.B. 20, Bori, Rivers State, Nigeria.
Joy S. Ekechi
Department of Microbiology, Faculty of Science, Rivers State University, P.M.B. 5080, Nkpolu-Oroworukwo, Port Harcourt, Nigeria.
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