Evaluation of Toxicity on Mice and Artemicidal Activity of Bauhinia monandra Leaf Lectin (BmoLL)

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Evaluation of Toxicity on Mice and Artemicidal Activity of Bauhinia monandra Leaf Lectin (BmoLL)

November 19, 2019 Microbiology and Biotechnology 0

Aims: This work aimed to determine the toxicity of Bauhinia monandra leaf lectin (BmoLL) to mice and Artemia salina.

Study design: BmoLL was purified from the leaves of B. monandra through affinity chromatography and tested against mice and A. salina in order to evaluate its toxicity.

Methodology: The lectin purification was performed through saline precipitation and chromatography onto a guar gel column. The acute toxicity of BmoLL was evaluated using female mice during 14 days. Toxicity of BmoLL to A. salina larvae was also evaluated.

Results: BmoLL did not induce death or weight loss of mice at 2000 mg/kg b.w.; additionally, the lectin did not affect the survival of A. salina at the assayed concentrations (250–1,000 µg/mL).

Conclusion: BmoLL is an interesting molecule to investigate pharmacological applications due to its low toxicity according to the two models used in this work.

For more information contact author

Luana Cassandra Breitenbach Barroso Coelho
Departamento de Enfermagem, Faculdade dos Palmares – FAP, Palmares, Pernambuco, CEP 55540-000, Brazil.
Colegiado de Ciências Farmacêuticas, Universidade Federal do Vale do São Francisco – UNIVASF, Petrolina, Pernambuco, CEP 56304-917, Brazil.
Departamento de Bioquímica – CCB, Universidade Federal de Pernambuco – UFPE, Cidade Universitária, Recife, Pernambuco, CEP 50670-420, Brazil.
Centro Acadêmico do Agreste, Universidade Federal de Pernambuco – UFPE, Caruaru, Pernambuco, CEP 50670-901, Brazil.
Departamento de Medicina, Universidade de Pernambuco – UPE, Garanhuns, Pernambuco, CEP 55295-110, Brazil.
E-mail: lcbbcoelho@gmail.com

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