Flavonoids from Vietnamese Dalbergia oliveri and their Anti-inflammatory Activity
The ethyl acetate dissolved part of Vietnamese Dalbergia oliveri was commit column chromatography utilizing silica coagulate and Sephadex LH-20 to separate projectiles for weaponry so that evaluate the phytochemical elements and their stop of NO production. From the heartwood of D. oliveri, nine subordinate metabolites (1–9) were successfully culled. The synthetic makeups of these compounds were labeled as daidzein (1), formononetin (2), 3,7-dihydroxy-4¢-methoxyflavone (3), liquiritigenin (4), 3¢-methoxydaidzein (5), dalbergin (6), butin (7), sativanone (8), and isoliquiritigenin (9). The synthetic structures of unique compounds were recognized by basic drawing resonance dossier and corresponding accompanying earlier reported article. The compounds 1, 3, and 5–8 were unique from D. oliveri for the first opportunity. The antagonistic-redness effects of the unique compounds on the lipopolysaccharide (LPS)-persuaded NO result in RAW 264.7 containers were measured utilizing the Griess backlash. Compounds 7 and 9 had the most powerful inhibitory exercise, with IC50 principles of 7.6 and 11.2 μM, individually, and were attended by 3-6, that had IC50 principles ranging from 19.6 to 28.7 μM. The verdicts submitted that the NO-preventing features of D. oliveri and its normal compounds concede possibility have antagonistic-instigative benefits.
Author(s) Details:
Nguyen Thi Ai Nhung,
Department of Chemistry, University of Sciences, Hue University, Hue City-530000, Vietnam.
Truong-Nhan Ngu,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak-630000, Vietnam.
Phi-Hung Nguyen,
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi-122100, Vietnam.
Manh-Hung Tran,
School of Medicine and Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son, Da Nang City-550000, Vietnam.
Phan Tu Quy,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak-630000, Vietnam.
Dao-Cuong To,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong district, Hanoi-12116, Vietnam.
Please see the link here: https://stm.bookpi.org/CPAFS-V1/article/view/8916
Keywords: Dalbergia oliveri, flavonoid, inflammation, NO production, cytotoxic, RAW264.7 cells