Hypoxic Preconditioning. Search for a Predictor of Its Efficiency

Science Press Release Distribution Services

Hypoxic Preconditioning. Search for a Predictor of Its Efficiency

September 28, 2020 Medical Science 0

The resistance (T, the time before apnoea) to extreme hypobaric hypoxia (SHBH) is prolonged by a single mild hypobaric hypoxia (HBH). There is strong therapeutic potential for this hypoxic preconditioning effect. In our analysis with medium, moderate and high SHBH on intact rats and those pre-tested under SHBH  We found resistance to it, that the hypoxic preconditioning removed the discrepancies between groups of rats with different innate resistance to it and with different previous hypoxic experiences in resistance to extreme hypoxia. To assume that the hypoxic preconditioning is realised on its own was rational.  Mechanisms. Mechanisms. Methods for predicting the efficacy of pre-conditioning action were required to investigate these processes, but these methods were not available. In the quest process, we discovered in the intact rats a clear correlation in the acoustic startle reaction model, which we called the PPI-T test, between the efficiency of HBH and prepulse inhibition (PPI). In neurobiology and psychiatry, this model is commonly used; PPI, however, has not previously been used as a predictor of hypoxic preconditioning. We have, therefore, shown its validity. In order to predict the efficiency of the preconditioning action on intact animals and to research its mechanisms, the PPI-T test can be used.

Author (s) Details

Elena I. Zakharova
Laboratory of General Pathology of Cardiorespiratory System, Institute of General Pathology and Pathophysiology, Baltic Street 8, 125315 Moscow, Russia.

Zinaida I. Storozheva
Laboratory of Clinical Neurophysiology, Serbsky’ National Medical Research Center for Psychiatry and Narcology, Kropotkinsky per., 23, 111395 Moscow, Russia.

Andrey T. Proshin
Laboratory of Functional Neurochemistry, P.K. Anokhin’ Institute of Normal Physiology, Baltic Street 8, 125315 Moscow, Russia.

Mikhail Yu. Monakov
Laboratory of General Pathology of Cardiorespiratory System, Institute of General Pathology and Pathophysiology, Baltic Street 8, 125315 Moscow, Russia.

Alexander M. Dudchenko
Laboratory of General Pathology of Cardiorespiratory System, Institute of General Pathology and Pathophysiology, Baltic Street 8, 125315 Moscow, Russia.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/272

 

Leave a Reply

Your email address will not be published. Required fields are marked *