Impact of a Marine Algae against Oxidative Stress Induced Alzheimers in Animal Model
Aluminium is a neurotoxic metal that causes neurological diseases such as Alzheimer’s disease. Due to its existence in food, air, water, pharmaceuticals, and as floculating agents in the water purification process, chronic exposure to it is a genuine possibility. Controlling its toxicity through natural sources is crucial, hence the current study looked at the neuroprotective potential of Sargassum ilicifolium against aluminium induction. To produce cognitive impairment in rats, 100mg/kg b.wt of aluminium chloride was given orally. The ethanolic extract and ethyl acetate fraction of doses 100, 200, 400mg/kg and 200mg/kg, respectively, were chosen and administered from the 21st day of aluminium induction to the 40th day, and behavioural studies, antioxidant studies, neurotransmitter estimation, and finally histopathological studies were performed in drug-treated animals. The study found a possible neuroprotective impact via improving learning memory status in behavioural trials, reversing stress-induced free radicals, and increasing the levels of neurotransmitters involved in memory consolidation.
Author (S) Details
SRM College of Pharmacy, SRM University, Kattankulathur, India.
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