Influence of Depleted Complement Activity on the Development of Zymosan-Induced Arthritis
Zymosan-induced arthritis is a rheumatoid arthritis model that is used to study the cells and molecules that play a role in the pathogenesis of inflammatory joint diseases. Despite the fact that the alternative pathway of complement activity plays a role in the pathogenesis of arthritis, several questions remain unanswered. The aim of this study was to see how complement depletion affected cartilage integrity, Dectin-1 expression, and blood monocyte and lymphocyte apoptosis. The decomplementation was done with cobra venom factor (CVF), a peptide fragment that can activate the alternative complement pathway and is similar to C3 part. CVF treatment minimised proteoglycan loss and had a differential effect on Dectin-1 expression on monocyte and lymphocyte populations, as well as a reduction in the number of dendritic cells (DCs) in the synovial fluid. Complement inhibition’s performance in experimental models promotes the development of new therapeutic methods for human rheumatoid arthritis.
Author (s) Details
Department of Biology, Medical Genetics and Microbiology, Faculty of Medicine, Sofia University “St. Kliment Ohridsky”, Bulgaria.
Department of Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
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