Investigating the Possible Cardio-Protective Effects of Telmisartan against 5-Fluorouracil- Induced Cadiotoxicity in Wister Rats

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Investigating the Possible Cardio-Protective Effects of Telmisartan against 5-Fluorouracil- Induced Cadiotoxicity in Wister Rats

July 3, 2021 Pharmaceutical 0

The purpose of this study was to look into the protective effects of telmisartan against 5-FU-induced cardiotoxicity in Wister rats. Methods: Thirty-six Wister rats were divided into six groups at random: I, a negative control who received normal saline (2 ml/kg) orally for 30 days; II, a positive control who received normal saline (2 ml/kg/day) orally for 25 days and then received 5-Fluorouracil (5-FU) (20 mg in 2 ml normal saline per kg body weight) once daily by intraperitoneal injection in conjunction with normal saline. saline for 5 days; I and, receiving telmisartan (5mg and 10mg/kg/day) for 30 consecutive days; and, receiving telmisartan (5mg and 10mg/kg/day) orally for 25 days, and then receiving 5-FU (20 mg in 2ml normal saline per kg body weight) once daily by intraperitoneal injection in association with normal saline for 5 days. Telmisartan prophylactic treatment significantly reduces serum cardiac troponin T, aspartate aminotransferase (AST), and alanine levels. Elevated aminotransferase (ALT) due to 5-FU-induced cardiotoxicity. Conclusion: The current findings suggest that telmisartan may be a useful modulator in the prevention of 5-FU-induced cardiotoxicity.

Author (S) Details

Alaa Radhi Khudhair
Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad, Iraq.

Intesar T. Numan
Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad, Iraq.

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