Investigation on the Anti-ulcerogenic Effects and Anti-oxidative Properties of Ceiba pentandra Leaves on Alloxan-induced Diabetic Rats

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Investigation on the Anti-ulcerogenic Effects and Anti-oxidative Properties of Ceiba pentandra Leaves on Alloxan-induced Diabetic Rats

November 6, 2020 Pharmaceutical 0

It has been shown that many natural products, mainly of plant origin, have promising practises that could help prevent and/or improve disease prevention. Gastric ulcer is a gastrointestinal tract ulceration arising from repeated erosions and stomach wall damage that can become perforated and develop into peritonitis and massive haemorrhage. Objectives: The current research aimed to assess the protective effects of Ceiba pentandra leaves methanol extract on gastric ulcers induced by indomethacin and ethanol and on oxidative stress indices of diabetic rats induced by alloxan. Location and length of study: Department of Biochemistry, University of Nigeria, Nsukka. Nature of the study: extraction and administration of graded doses of the extract. State of Enugu, Nigeria, from May, 2011 through October, 2011. Methodology: Ceiba pentandra leaves were extracted using methanol. For each of the ulcer experiments, 20 adult rats, split into five groups of four rats each, were used. In rats, gastric ulceration was caused by oral administration of indomethacin (50 mg / kg) and 95% ethanol (0.5 ml) thirty minutes after extract therapy and sacrificed to animals 8 hours later. Thirty (30) albino rats, divided into six (6) groups of five (5) rats each, were used for the diabetes research. Diabetes was induced by i.p. injection of alloxan monohydrate (150 mg / kg) for two weeks in overnight fasting animals and animals treated with a range of extract doses (100 , 200 and 400 mg / kg). For the determination of lipid profile and liver marker enzymes, serum obtained from the diabetic rats was used. Results: inhibition of severe and dose-dependent ulcers (70, 82 and 84 percent; 19, 53, and 58 percent for 100 , 200, and 400 mg / kg extracts, respectively) were developed for the ulcer models used in all extract-treated classes. Important reductions (p<0.05) were reported in fasting blood glucose, liver marker enzymes, total cholesterol, low density lipoprotein and triacylglycerides relative to those of the diabetes-untreated community in the serum of the extract-treated groups. Conclusion: The results of this study indicate that Ceiba pentandra leaves methanol extract has good anti-ulcerogenic and anti-oxidative properties and has the potential to be used as a herbal remedy for the treatment of gastrointestinal ulcers and diabetes control.

Author(s) Details

Dr. C. A. Anosike
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

S. C. Abugu
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

J. C. Ugwu
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.

P. C. Ojeli
Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.



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