Latest News on blood count : July – 2020
The complete blood count: physiologic basis and clinical usage
The complete blood count is one of the most frequently ordered laboratory tests in medicine. The components are the red blood cell count, hemoglobin, hematocrit, red blood cell indices (including the mean cell volume, mean cell hemoglobin, mean cell hemoglobin concentration, and red cell distribution width), reticulocyte count, white blood cell count and differential, and platelet count. To aid in understanding the multiple uses of the complete blood count, the article discusses the function, life cycle, and physiology of the various cell components. In addition, the characteristics of the various tests, including their strengths and limitations, are presented. This information can be helpful in difficult diagnoses and in monitoring treatments for hematologic disorders and other medical problems. 
Method of determining a complete blood count and a white blood cell differential count
Systems and methods analyzing body fluids such as blood and bone marrow are disclosed. The systems and methods may utilize an improved technique for applying a monolayer of cells to a slide to generate a substantially uniform distribution of cells on the slide. Additionally aspects of the invention also relate to systems and methods for utilizing multi color microscopy for improving the quality of images captured by a light receiving device. 
Understanding the complete blood count with differential
The complete blood count (CBC) with differential is one of the most common laboratory tests performed today. It gives information about the production of all blood cells and identifies the patient’s oxygen-carrying capacity through the evaluation of red blood cell (RBC) indices, hemoglobin, and hematocrit. It also provides information about the immune system through the evaluation of the white blood cell (WBC) count with differential. These tests are helpful in diagnosing anemia, certain cancers, infection, acute hemorrhagic states, allergies, and immunodeficiencies as well as monitoring for side effects of certain drugs that cause blood dyscrasias. Nurses in the perianesthesia arena are frequently challenged to obtain and evaluate all or parts of the CBC as a part of the patient’s preoperative, intraoperative, and postoperative assessments. An enhanced understanding of this laboratory test is essential to providing quality care. © 2003 by American Society of PeriAnesthesia Nurses. 
Association of Plasma Lead with Iron Indices and Complete Blood Count among Male Bricklayers in Ibadan, Oyo State
Background: Analysis of cement dust by various investigators has revealed that its contents include mercury (Hg), copper (Cu), chromium (Cr), cadmium (Cd), Nickel (Ni), Manganese (Mn) and lead (Pb). Few studies done among cement factory workers in Nigeria showed conflicting results in haematological parameters which could not be related to any particular heavy metals. This necessitated the need for this study.
Objective: This study aims to relate lead level with iron indices and complete blood count among bricklayers.
Methods: Comparative cross sectional study among 45 bricklayers and 45 age and sex matched tailors. Questionnaire was administered to find out occupational practice. Plasma was analyzed for lead by Atomic Absorption spectrometer (AAS) while serum was analyzed for ferittin and iron by ELISA and photometric method respectively. Total Iron Binding Capacity (TIBC) and percentage Transferin saturation (%TFS) were derived by calculation while complete Blood Count (CBC) was determined using a Sysmex Kx21 auto-analyser.
Results: Eighty seven percent of the bricklayers practice their profession without protective coverings. There was a significant increase in the plasma level of lead (p=.00) but decrease in ferrittin among bricklayers compared with controls (p=.00).
Bricklayers with blood lead level above acceptable level (5 µg/dl) had significantly reduced ferittin (p=0.04).
Conclusion: In this study showed a relatively lower serum ferritin level among bricklayers which was more pronounced with increasing lead level. This may suggest depletion of iron store with increasing lead level. The use of protective measures such as gloves, facemasks and protective garments when in contact with cement and regular medical checkups to prevent depletion of iron store and its consequences are hereby suggested. 
Effect of Zinc Supplementation on Blood Pressure and Complete Blood Count in Hemodialysis Patients
Objectives: Zinc is an important trace element in human nutrition and its deficiency is a worldwide problem. Zinc deficiency incidence is predominantly high in many diseases such as ESRD (End Stage Renal Disease) patients undertaking hemodialysis (HD). Beside, hypertension and cardiac output, is a predictor of cardiovascular mortality in HD patients. This study investigated the effects of zinc supplementation on blood pressure (BP) and complete blood count (CBC) in HD patients.
Materials and Methods: In a randomized, double-blind, and placebo-controlled trial, Sixty-five HD patients were randomly divided into two groups. Patients in group I and group II received placebo and Zn supplementation (100 mg/day) respectively for two months. After withdrawing for the duration of the next two months, the study was continued as a crossover design for another two months (group I and II received zinc supplementation and placebo, respectively). Systolic and diastolic BP, cardiac ejection fraction (EF), and CBC were measured at the 0th, 60th, 120th, and 180th days. Statistical analyses were performed using SPSS software.
Results: Zinc supplementation resulted in a significant increase in the mean red blood cell (RBC), Hematocrit (Hct), whereas a significant decrease was seen in systolic and diastolic BP. Changes observed in the placebo group were not significant.
Conclusion: Zinc supplementation for two months improved the systolic and diastolic BP, RBC, and Hct in HD patients. 
 Dixon, L.R., 1997. The complete blood count: physiologic basis and clinical usage. The Journal of perinatal & neonatal nursing, 11(3), pp.1-18.
 Winkelman, J., Tanasijevic, M. and Zahniser, D., Roche Diagnostics Hematology Inc, 2015. Method of determining a complete blood count and a white blood cell differential count. U.S. Patent 9,017,610.
 George-Gay, B. and Parker, K., 2003. Understanding the complete blood count with differential. Journal of PeriAnesthesia Nursing, 18(2), pp.96-117.
 Ojo, O. T., Fasola, F. A., Olawale, O. O., Akinpelu, A., Anetor, J. I., Olatunji, P. O. and Shokunbi, W. A. (2015) “Association of Plasma Lead with Iron Indices and Complete Blood Count among Male Bricklayers in Ibadan, Oyo State”, Journal of Advances in Medicine and Medical Research, 11(12), pp. 1-9. doi: 10.9734/BJMMR/2016/21904.
 Mazani, M., Argani, H., Rashtchizadeh, N., Banaei, S., Kazemi Arbat, B. and Rezagholizadeh, L. (2017) “Effect of Zinc Supplementation on Blood Pressure and Complete Blood Count in Hemodialysis Patients”, Asian Journal of Medicine and Health, 7(3), pp. 1-10. doi: 10.9734/AJMAH/2017/35265.