Latest News on Ovarian Cancer Research: Nov – 2019

Science Press Release Distribution Services

Latest News on Ovarian Cancer Research: Nov – 2019

November 25, 2019 Gynaecology and Obstetrics 0

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2

Epithelial sex gland cancer contains a major transmitted element, however the far-famed condition genes justify but [*fr1] the surplus familial risk1. we tend to performed a genome-wide association study (GWAS) to spot common sex gland cancer condition alleles. we tend to evaluated 507,094 SNPs genotyped in one,817 cases and a couple of,353 controls from the united kingdom and ∼2 million imputed SNPs. we tend to genotyped the twenty two,790 high hierarchic SNPs in four,274 cases and four,809 controls of European ancestry from Europe, USA and Australia. we tend to known twelve SNPs at 9p22 related to sickness risk (P < 10−8). [1]

Opportunistic salpingectomy: uptake, risks, and complications of a regional initiative for ovarian cancer prevention

Objective: the aim of this study was to assess the uptake Associate in Nursingd perioperative safety of bilateral ablation (BS) as an sex gland cancer risk-reduction strategy in low-risk ladies when a regional initiative that was aimed toward general gynecologists within the province of British Columbia, Canada.

Study Design: This population-based retrospective cohort study evaluated forty three,931 ladies in British Columbia from 2008-2011 WHO underwent cutting out that was performed with and while not BS or bilateral salpingo-oophorectomy or who underwent surgical sterilization by means that of BS or surgical contraception. Parameters that were examined embrace patient age, in operation time, surgical approach, indication, length of hospital keep, and perioperative complications. [2]

FAILURE OF SECOND-LOOK LAPAROTOMY TO INFLUENCE SURVIVAL IN EPITHELIAL OVARIAN CANCER

The survival advantage of second-look section when completion of primary therapy in patients with animal tissue sex gland cancer has been assessed in an exceedingly prospective randomized trial of 166 patients. Patients were randomized into 3 teams. All were ab initio treated with cisplatin (100 mg/m2 × 5) when primary section. blood group (n=53) was scheduled  to possess a second-look section, followed by alternating oral Leukeran. type B (n=56) was scheduled  to possess a second-look section, followed by total abdominal and girdle irradiation, and cluster C (n=57) received oral Leukeran as for blood group however had no second-look operation. With a median follow from forty six months (range 21-64), no variations in survival were noted between the 3 teams. The median survival for blood group was twenty one months (95% CI 11-31 months), for type B fifteen months (11-19), and for cluster C seventeen months (8-26). [3]

MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis

Ovarian cancer selective metastasizes to the peritoneum contributive to the poor prognosis related to sex gland cancer. However, the mechanism underlining this propensity and therapeutic approaches to counter this method has not been absolutely elucidated. Here, we tend to show that MCP-1 created by omental adipocytes binding to its cognate receptor CCR-2 on sex gland cancer cells facilitates migration and omental metastasis by activating the PI3K/AKT/mTOR pathway and its downstream effectors HIF-1α and VEGF-A in cell lines, xenografts, and transgenic murine models. MCP-1 protein considerably remittent tumour burden and raised survival of mice in vivo. [4]

The Therapeutic Impact of Lymphadenectomy in the Management of Epithelial Ovarian Cancer: A Single Institution Experience

Aim: To assess the impact of lymphadenectomy on overall survival (OS) and progression-free survival (PFS) in patients with animal tissue sex gland cancer (EOC).

Study Design: Retrospective empirical  study.

Place and length of Study: All patients diagnosed with animal tissue sex gland, oviduct or primary serosa cancer treated within the Department of gynecological medicine in an exceedingly tertiary care hospital in South Republic of India from Jan 2012 ahead. All patients’ follow up information was prospectively updated until thirty Gregorian calendar month 2017.

Methodology: we tend to enclosed eighty three patients United Nations agency met the inclusion criteria. The patients were classified into 2 teams supported the amount of humour nodes (LN) harvested (< thirty humour nodes and > thirty nodes). Lymphadenectomy was thought of systematic (SLND) once the harvest was > thirty nodes on the pathologic specimen. [5]

Reference

[1] Song, H., Ramus, S.J., Tyrer, J., Bolton, K.L., Gentry-Maharaj, A., Wozniak, E., Anton-Culver, H., Chang-Claude, J., Cramer, D.W., DiCioccio, R. and Dörk, T., 2009. A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22. 2. Nature genetics, 41(9), (Web Link)

[2] McAlpine, J.N., Hanley, G.E., Woo, M.M., Tone, A.A., Rozenberg, N., Swenerton, K.D., Gilks, C.B., Finlayson, S.J., Huntsman, D.G., Miller, D.M. and of British, O.C.R.P., 2014. Opportunistic salpingectomy: uptake, risks, and complications of a regional initiative for ovarian cancer prevention. American journal of obstetrics and gynecology, 210(5), (Web Link)

[3] Luesley, D., Blackledge, G., Kelly, K., Wade-Evans, T., Fielding, J., Lawton, F., Hilton, C., Rollason, T., Jordan, J., Latief, T. and Chan, K.K., 1988. Failure of second-look laparotomy to influence survival in epithelial ovarian cancer. The Lancet, 332(8611), (Web Link)

[4] MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis
Chaoyang Sun, Xi Li, Ensong Guo, Na Li, Bo Zhou, Hao Lu, Jia Huang, Meng Xia, Wanying Shan, Beibei Wang, Kezhen Li, Danhui Weng, Xiaoyan Xu, Qinglei Gao, Shixuan Wang, Junbo Hu, Yiling Lu, Gordon B. Mills & Gang Chen
Oncogene (2019) (Web Link)

[5] Kulkarni, K., Premalatha, T. S., Sumangala, G., Acharya, G., Selvam, S., C. Bidkar, V., Crasta, J. and Vallikad, E. (2018) “The Therapeutic Impact of Lymphadenectomy in the Management of Epithelial Ovarian Cancer: A Single Institution Experience”, Journal of Cancer and Tumor International, 8(1), (Web Link)

 

Leave a Reply

Your email address will not be published. Required fields are marked *