Latest Research on Hypertension: Jan – 2020

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Latest Research on Hypertension: Jan – 2020

January 22, 2020 Cardiology 0

Hypertension Canada’s 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults

Hypertension Canada provides annually updated, evidence-based guidelines for the diagnosis, assessment, prevention, and treatment of hypertension. This year, we introduce 10 new guidelines. Three previous guidelines are revised and 5 are removed. Previous age and frailty distinctions are removed as considerations for when to initiate antihypertensive therapy. within the presence of macrovascular organ damage, or in those with independent cardiovascular risk factors, antihypertensive therapy should be considered for all individuals with elevated average systolic nonautomated office vital sign (non-AOBP) readings ≥ 140 torr . for people with diastolic hypertension (with or without systolic hypertension), fixed-dose single-pill combinations are now recommended as an initial treatment option. Preference is given to pills containing an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker together with either a calcium channel blocker or diuretic. [1]

Primary Pulmonary Hypertension

Primary pulmonary hypertension may be a condition characterized by sustained elevations of pulmonary-artery pressure without a demonstrable cause. The diagnostic criteria utilized in the National Institutes of Health (NIH) registry1 include a mean pulmonary-artery pressure of quite 25 torr at rest, or quite 30 torr with exercise, and therefore the exclusion of left-sided cardiac valvular disease, myocardial disease, congenital heart condition , and any clinically important respiratory, connective-tissue, or chronic thromboembolic diseases. Pulmonary vascular disease with clinical and pathological features almost like those of primary pulmonary hypertension can occur in patients with malignant hypertension ,2 infection with the human immunodeficiency. [2]

Exercise and Hypertension

Hypertension (HTN), one among the foremost common medical disorders, is related to an increased incidence of all-cause and disorder (CVD) mortality. Lifestyle modifications are advocated for the prevention, treatment, and control of HTN, with exercise being an integral component. Exercise programs that primarily involve endurance activity prevent the event of HTN and lower vital sign (BP) in adults with normal BP and people with HTN. The BP lowering effects of exercise are most pronounced in people with HTN who engage in endurance exercise with BP decreasing approximately 5–7 torr after an isolated exercise session (acute) or following exercise training (chronic). Moreover, BP is reduced for up to 22 h after an endurance exercise bout (e.g., postexercise hypotension), with the best decreases among those with the very best baseline BP. [3]

Body mass index modifies the association between frequency of alcohol consumption and incidence of hypertension in men but not in women: a retrospective cohort study

Alcohol consumption is one among the main modifiable risk factors of hypertension. The aim of this retrospective study was to assess the clinical impact of obesity on the association between alcohol consumption and therefore the incidence of hypertension. this study included 5116 male and 6077 female university employees with a median age of 32 (interquartile range 27–39) who underwent annual health checkups between January 2005 and March 2013. Self-reported drinking frequency was recorded at their first checkup and categorized into rarely and 1–3, 4–6, and seven days/week. [4]

Impact of Experimental Development of Arterial Hypertension and Dyslipidemia on Intravascular Activity of Rats’ Platelets

Great interest is shown by researchers to functional and rheological features of basic regular blood elements. Platelets are among them and take the foremost active part in hemostasis at rather wide-spread nowadays cardio-vascular and metabolic diseases. The aim is to research dynamics’ strengthening of platelets’ intravascular activity of rats in conditions of experimental consequent development of arterial hypertension and dyslipidemia. The study used 68 male-rats of Vistar line at the age of two .5-3 months. Control group was composed of 33 animals. Experimental animals (35 rats) were developed initially – arterial hypertension (usage of cardioangiol pathogenic diet for two weeks and impact of cold at the end) then – dyslipidemia (application of rich in calories diet at lowering of motor activity). [5]

Reference

[1] Leung, A.A., Daskalopoulou, S.S., Dasgupta, K., McBrien, K., Butalia, S., Zarnke, K.B., Nerenberg, K., Harris, K.C., Nakhla, M., Cloutier, L. and Gelfer, M., 2017. Hypertension Canada’s 2017 guidelines for diagnosis, risk assessment, prevention, and treatment of hypertension in adults. Canadian Journal of Cardiology, 33(5), (Web Link)

[2] Rubin, L.J., 1997. Primary pulmonary hypertension. New England Journal of Medicine, 336(2), (Web Link)

[3] Pescatello, L.S., Franklin, B.A., Fagard, R., Farquhar, W.B., Kelley, G.A. and Ray, C.A., 2004. Exercise and hypertension. Medicine & Science in Sports & Exercise, 36(3), (Web Link)

[4] Body mass index modifies the association between frequency of alcohol consumption and incidence of hypertension in men but not in women: a retrospective cohort study
Daiki Nishigaki, Ryohei Yamamoto, Maki Shinzawa, Yoshiki Kimura, Yoshiyuki Fujii, Katsunori Aoki, Ryohei Tomi, Shingo Ozaki, Ryuichi Yoshimura, Manabu Taneike, Kaori Nakanishi, Makoto Nishida, Keiko Yamauchi-Takihara, Yoshitaka Isaka & Toshiki Moriyama
Hypertension Research (2020) (Web Link)

[5] Skoryatina, I. A. and Zavalishina, S. Y. (2017) “Impact of Experimental Development of Arterial Hypertension and Dyslipidemia on Intravascular Activity of Rats’ Platelets”, Annual Research & Review in Biology, 14(5), (Web Link)

 

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