Liver Transplantation Studies Using a Canine Model: A Zoom on the Intermediate Filaments of the Cytoskeleton of the Hepatocytes
Liver transplantation can be used to treat both acute and chronic liver insufficiency. Graft malfunction persists in the twenty-first century. It affects up to one-third of those who receive it, despite reports of good to exceptional long-term outcomes. The etiologic examination of organ dysfunction revealed a complex basis at the time of authoring this chapter. Ischemia and reperfusion (I/R) injury is arguably the most major contributing factor for organ dysfunction, despite the numerous etiology. Cholestasis, or the cessation or reduction of bile flow with or without bile, is a condition in which the flow of bile is stopped or reduced. I/R damage is frequently accompanied with duct loss or ductopenia, as well as biliary ductular proliferations. They can, however, be deceiving, as they can also be present in other types of graft malfunction. Biliary marker levels often rise within 5 days of donation. The intermediate filaments of the cytoskeleton were studied in detail in this chapter using a liver transplantation model as an I/R damage model. The phenotypic flip of hepatocytes occurs before frank cholestasis, according to our findings. We believe that focusing on this phenotypic transformation in liver cells could aid in the savage or improved fate of the liver transplantation.
Author (s) Details
Consolato M. Sergi
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada and Stollery Children’s Hospital, University Alberta Hospital, Edmonton, AB, Canada.
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