Mechanism of Alternative Splicing in Cancer Therapy
Alternative splicing is an essential mechanism by which the rearrangement of exons and introns contributes to the development of multiple proteins from a single gene. It is one of the key drivers of the variety of proteomas. The spliceosome is the macromolecular machinery that mediates the alternative splicing process through a multi-step process involving small nuclear ribonuclear protein (snRNP) sequential binding and release. A complex process that is closely regulated by SR proteins, hnRNPs and many splicing factors is alternative splicing. A variety of illnesses, including cancer, are associated with aberration of alternative splicing patterns. The path of a disease can be altered or precluded by modulating alternative splicing. This review focuses on the function of alternative splicing in the production of cancer, the alteration of cancer splicing factors, small splicing-inhibiting molecules, the targeting of splicing regulators, and the use of oligonucleotides that can be used in cancer therapy as potential therapeutic strategies.
Biochemistry Department, Federal University of Technology, P.M.B. 65, Minna, Niger State,Nigeria.
Prof. Evans Egwim
Centre for Genetic Engineering and Biotechnology, Federal University of Technology, P.M.B. 65, Minna, Niger State, Nigeria.
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