Nanoparticles for Modulation of Astrocyte Physiology: A Possible Therapeutic Agent to Control Brain Hyper-Excitability
Hyper-excitability of the brain is an irregular condition of the brain that occurs due to a neuron’s burst firing. In a normal brain, astrocytes modulate neuronal activities, so brain hyper-excitability is also related with astrocyte physiology. Scientists suggest that astrocyte regulation could be a choice for regulating hyperactive brain disorders. Various nano-particles are designed to regulate the role of the astrocyte to monitor hyper-excitability of the brain and prevent brain disease. To regulate the membrane potential of the astrocyte, charged nanoparticles are either incorporated into the lipid bi-layer or attached to the channel protein present in the plasma membrane. Up to now, none of the approaches are completely successful in regulating brain hyper-excitability.
Author (s) Details
Dr. Manash Barthakur
Department of Zoology, Pub Kamrup College, Kamrup Assam, 781381, India.
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