Natural Acid Catalyzed Synthesis and Biological Evaluation of Dihydropyrimidinone Derivative Synthesied from Vanillin, Ethylacetoacetate and Urea

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Natural Acid Catalyzed Synthesis and Biological Evaluation of Dihydropyrimidinone Derivative Synthesied from Vanillin, Ethylacetoacetate and Urea

November 11, 2020 Chemical Science 0

In recent years, green synthesis of organic compounds using solvent-free conditions has gained popularity, as most solvents are either poisonous or flammable. In the field of natural and synthetic organic chemistry, dihydropyrimidinones are very significant heterocyclic motifs. The natural acid catalyst is used for organic synthesis, which catalyses different organic transformations efficiently. A green methodology for the synthesis of the dihydropyrimidinone derivative is the objective of the present study. The present study focuses on the synthesis, characterization and biological evaluation of vanillin, ethylacetoacetate and urea derivatives of dihydropyrimidinone ethyl-4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate using gooseberry extract. The antimicrobial activity indicates that the synthesised dihydropyrimidinone can be used to treat microbial diseases. The synthesised compound is characterised by spectroscopy of UV-Visible and FT-IR. Antibacterial , antifungal, antioxidant and anti-helminthic activities are seen in the synthesised compound. This natural acid catalysed synthesis is safe, environmentally friendly and does not use hazardous materials and quantifies it as a green approach to organic compound synthesis.

Author(s) Details

Dr. Sheeba Daniel
Department of Chemistry and Research Centre, Holy Cross College (Autonomous), Nagercoil- 629004, Tamil Nadu, India.

K. Saraniya
Department of Chemistry and Research Centre, Holy Cross College (Autonomous), Nagercoil- 629004, Tamil Nadu, India.

P. Vinitha
Department of Chemistry and Research Centre, Holy Cross College (Autonomous), Nagercoil- 629004, Tamil Nadu, India.

T.R. Scotlin Blessy
Department of Chemistry and Research Centre, Holy Cross College (Autonomous), Nagercoil- 629004, Tamil Nadu, India.

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