Neurological Pain Study in Animals with Proposed Analgesic Mechanism Profiles

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Neurological Pain Study in Animals with Proposed Analgesic Mechanism Profiles

July 3, 2021 Pharmaceutical 0

Pain is the most natural sensation in our bodies, and it plays an important role in protecting all organisms from severe harm. It is the most complicated topic in neurological research of all time, and yet no scientist has been able to clearly justify all of the mechanisms mediated by pain receptors. Of course, there have been some solutions to pain relief, which can be life-saving in a variety of situations, including chronic and acute pain conditions. Scientists have been investigating this for decades, using pain-like behavioral study methodologies in conscious animals to characterize the analgesic profile for pain regulation development. Nonetheless, the methodology is widely used. There has rarely been a comprehensive review of all of these methodologies, their benefits and drawbacks, as well as the mechanism of action involved. Thus, this topic focuses solely on the complete protocol that is being adapted in each animal’s “pain-like” behavioral study that is induced by analgesic agents, the various assessment methods used for inflammatory pain, and the mechanistic actions underlying each behavioral study methodology. This in-depth discussion will provide a concise idea and improve our scientists’ understanding of pain management.

Author (S) Details

Chuan Wei Oo
Department of Organic Chemistry, School of Chemical Sciences, University Sains Malaysia, 11800 Minden, Penang, Malaysia.

Yean Chun Loh
Department of Organic Chemistry, School of Chemical Sciences, University Sains Malaysia, 11800 Minden, Penang, Malaysia.

Mun Fei Yam
Department of Pharmacology, School of Pharmaceutical Sciences, University Sains Malaysia, 11800 Minden, Penang, Malaysia.

Rusliza Basir
Department of Human Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia.

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