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Assessment and Quantification of Pharmacologically Active Marker Gallic Acid and Ellagic Acid from Leaf and Stem of Pergularia daemia Forsk. by HPTLC Method

A TLC densitometry method is developed for the quantification of gallic acid and ellagic acid using HPTLC. HPTLC is an important tool for determining chemical constituents in plant material. This is the first time that these two biologically active compounds, gallic acid and ellagic acid, have been quantified using HPTLC from this plant. Gallic acid…
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March 4, 2021 0

Centre-based Evaluation of Heamatological and Some Biochemical Effects of the Initial Phase of Anti-tuberculosis Therapy in Bayelsa State

The aim of this study was to determine the adverse effects of anti-tuberculosis drugs on blood and some biochemical parameters in patients with primary tuberculosis infection. Study Design: This study used a non-probability (purposive) sampling method. The research was performed at the Tuberculosis and Leprosy Referral Hospital’s Chest Clinic in Yenagoa, Bayelsa State, Nigeria. From…
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March 4, 2021 0

Photocatalytic Antibacterial Activity of TiO2, TiO2+CuO, and WO3 +CuO -Evaluation of Codoping Effect

Under UV irradiation to irritate active oxygen from the agents, the antibacterial efficacy of the photocatalysts TiO2, TiO2+CuO, and WO3+CuO was tested against E. coli, K. pneumoniae, MRSA, and P. aeruginosa. Drawing a bacterial growth curve, colony counting on a cultivated Petri dish, calculating generation time in liquid medium, and evaluating the bacteria’s survival rate…
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March 4, 2021 0

Promising Antimicrobial Activities of Malpighiaceae Family and Its Outcome for Oral Cavity Infectious Diseases

Current medical therapies for oral infectious diseases are limited by the specificity and tolerance of pathogenic bacteria, fungi, and viruses, necessitating the production of novel substances. Plants have long been a source of active chemical agents; however, in the case of Malpighiaceae, a flowering plant family with secondary metabolites that have shown a range of…
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March 4, 2021 0

Influence of Berberine on Megakaryocyte and Apoptotic Cell Populations in Erosive Arthritis

Berberine (BB) is a protoberberine alkaloid that has a broad range of pharmacological activities and is a Janus kinase (Jak)2/3 inhibitor. However, the mechanisms of berberine’s anti-inflammatory effects on joints are still unclear. The aim of this study was to see how berberine affected apoptosis and the generation of senescent cells. The tests were carried…
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March 4, 2021 0

Microneedle Aided Transdermal Delivery of Antimigraine Drugs

Microneedle (MN) assisted transdermal delivery is a new technology that enables drugs to pass through the skin’s stratum corneum barrier and increase their permeation. Due to hepatic first pass metabolism, antimigraine drugs Zolmitriptan (ZT) and Rizatriptan (RT) have low and variable bioavailability when administered as currently available formulations. To efficiently deliver these molecules, transdermal delivery…
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March 4, 2021 0

Studying Formulation and Physicochemical Characterization of Buccal Mucoadhesive Films Containing Alfuzosin Hydrochloride

The physiology of the mouth has allowed many drugs to be administered through the oral route. Another promising method for drug delivery is oral mucosal drug delivery, which has a range of advantages. The aim of this study was to embed a drug molecule, alfuzosin hydrochloride, in a sustained release buccal film for an 8-hour…
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March 4, 2021 0

A Review on Brown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance

Brown seaweed and marine invertebrates contain fucoidans, which are sulphated polysaccharides. They have anti-cancer properties because they target several signalling channels and molecular processes in cancerous cells. The chemical structure diversity of fucoidans, as well as their similarities to other molecules such as glycosaminoglycan, are defined in this study, allowing them to participate in a…
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March 4, 2021 0

Assessment of the Cytotoxicity, Cell Cycle Arrest and Pro-apoptotic Effects of Two African Botanicals, Lantana ukambensis (Vatke) Verdc and Balanites aegyptiaca (L.) Delile on Human Colorectal Cancer Cells

In African traditional medicine, the plants Lantana ukambensis (Vatke) Verdc. (Verbenaceae) and Balanites aegyptiaca (L.) Delile (Zygophyllaceae) are used to treat wounds and inflammatory diseases. The aim of this study is to see how the extracts and fractions of these plants affect HCT-116 and HT-29 cells in terms of cytotoxicity, cell cycle arrest, and pro-apoptotic…
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March 4, 2021 0

Reporting a Case with Literature Review: Sunitinib Use for Metastatic Renal Cell Carcinoma Associated with Necrotizing Cavitary Pulmonary Aspergillosis with Aspergillus Flavus

Chronic necrotizing cavitary pulmonary aspergillosis caused by sunitinib is a rare occurrence in the literature. The patient in this case had biopsy-proven papillary renal cell carcinoma, which was treated with radical nephrectomy at first. He presented with progressively worsening abdominal pain, headaches, and a 40-pound weight loss eight months later, and investigation revealed extensive retroperitoneal…
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March 4, 2021 0