Peptide Based Tuberculosis Treatment: A Million Dollar Question
Tuberculosis (TB) is a deadly tropical disease that is mainly caused by Mycobacterium tuberculosis. The pathogen is known to invade and replicate inside the host’s macrophage. Due to the emerging dilemma of multi-drug resistant TB and extensively-drug resistant TB, the exigency for finding new TB drugs is an obligation now. Among the propitious anti-tubercular agents studied in the past few decades, peptides from diversified sources have been substantiated to be persuasive with multiple advantages such as low immunogenicity, selective affinity to bacterial negatively charged cell envelopes and most importantly divergent mechanisms of action. This chapter highlights the role of prime peptides exploited from several other unplumbed sources as anti-tubercular agents.
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Department of Plant Biology and Biotechnology, Loyola College, Nungambakkam, Chennai-34, India.
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