Procalcitonin as a Diagnostic Biomarker of Sepsis: A Prospective Study in a Tertiary Care Centre

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Procalcitonin as a Diagnostic Biomarker of Sepsis: A Prospective Study in a Tertiary Care Centre

July 5, 2021 Medicine and Medical Science 0

Introduction: Despite advances in diagnostic methods, sepsis remains a significant cause of morbidity and mortality. It is still difficult to distinguish between sepsis and non-infectious disease conditions. The procalcitonin (PCT) test is useful for diagnosing sepsis, but the cut-off levels differ depending on the clinical situation. The goal of this study was to correlate serum PCT levels with cultures in order to determine the appropriate cut-off values for PCT with high sensitivity and specificity. Methodology: This prospective study included 305 patients from various hospital wards; the patients were divided into three groups: group I: controls (n = 46), group II: culture-negative sepsis (n = 76), and group III: sepsis (n = 76). PCT levels were significantly higher in groups II and III when compared to group I. The best PCT cut-off point in group II was 1.3 ng/ml, with 87.30 percent sensitivity and 78.26 percent specificity (area under curve 0.86). The best cut-off value in group III was 2.20 ng/ml, with 98.47 percent sensitivity and 89.13 percent specificity (AUC 0.96). Conclusion: Procalcitonin is a promising biomarker for the diagnosis of bacterial sepsis because it can distinguish between culture-negative and culture-positive sepsis from non-infectious diseases.

Author (S) Details

Shefali Gupta
Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Pradeep Jaswani
Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Raj K. Sharma
Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Suraksha Agrawal
Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Narayan Prasad
Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Chinmoy Sahu
Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Amit Gupta
Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Kashi N. Prasad
Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

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