Radiotherapy in Elderly Patients with Low-Risk Breast Cancer

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Radiotherapy in Elderly Patients with Low-Risk Breast Cancer

June 14, 2021 Medicine and Medical 0

Few studies on the treatment of older women with low-risk breast cancer have been conducted. Despite the fact that their clinical behaviour is identical to that of younger patients, they are frequently undertreated, which increases the likelihood of local relapses and shortens their survival. The rate of local recurrences after breast conserving surgery without adjuvant treatment (tamoxifen or radiation) is significant, approaching 20% in low-risk individuals, which is unacceptable. Despite the fact that tamoxifen and irradiation appear to have equal effects in terms of preventing local recurrence, The combination of the two produces the best overall survival rates, with local relapses of less than 2%. In recent years, two trials that were specially tailored for older patients were published. These trials propose avoiding radiotherapy in patients with low-risk tumours treated with breast conserving surgery and tamoxifen based on equal survival, but with a 10% increase in local relapses at 10 years vs. 2% when radiotherapy is skipped. There is no proof that taking tamoxifen can help you lose weight. is less toxic in this group of patients who are typically poly-treated, and treatment compliance appears to be much lower than expected. This recommendation is highly contentious due to the reduction in the number of sessions in external radiotherapy with hypofractionation and the acceleration of partial breast irradiation, especially intraoperative radiotherapy with a single session. After breast conserving surgery, elderly patients may benefit from radiation therapy.

Author (s) Details

Claudio Fuentes-Sánchez
Hospital Universitario Candelaria, Santa Cruz de Tenerife, Spain.

María Elena García-Morales
Hospital Universitario Candelaria, Santa Cruz de Tenerife, Spain.

Carmen González-San Segundo
Hospital Universitario Gregorio Marañón, Madrid, Spain.

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